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Mitochondrial ATP production and calcium buffering are critical for metabolic regulation and neurotransmission making the formation and maintenance of the mitochondrial network a critical component of neuronal health. Cortical pyramidal neurons contain compartment-specific mitochondrial morphologies that result from distinct axonal and dendritic mitochondrial fission and fusion profiles. We previously showed that axonal mitochondria are maintained at a small size as a result of high axonal mitochondrial fission factor (Mff) activity.
View Article and Find Full Text PDFRelative effects of seed mix design, consumer pressure, and edge proximity on community structure in restored prairies.
Ecol Appl
January 2025
Department of Plant Biology, Michigan State University, East Lansing, Michigan, USA.
A central goal of ecosystem restoration is to promote diverse, native-dominated plant communities. However, restoration outcomes can be highly variable. One cause of this variation may be the decisions made during the seed mix design process, such as choosing the number of species to include (sown diversity) or the number of locations each species should be sourced from (source diversity, manipulated to affect genetic diversity).
View Article and Find Full Text PDFThe Roles of Cannabis Potency and Gender in Cannabis Dependence and Anxiety in Recent Cannabis Users with Trauma Exposure Histories.
Pharmacol Res
January 2025
Department of Psychiatry, Dalhousie University, 5909 Veterans' Memorial Lane, 8th Floor, Abbie J. Lane Memorial Building, QEII Health Sciences Centre, Halifax, NS, B3H 2E2, Canada.
Over the past 20 years, levels of Δ9-tetrahydrocannabinol (THC) in cannabis have significantly increased, while levels of cannabidiol (CBD) have increased much less in comparison. Cannabis with higher THC potency (commonly assessed via THC:CBD ratio) may increase the risk for cannabis dependence and trigger/exacerbate anxiety. However, few studies of cannabis potency effects on cannabis dependence and anxiety have examined gender moderation.
View Article and Find Full Text PDFPalmitate potentiates the SMAD3-PAI-1 pathway by reducing nuclear GDF15 levels.
Cell Mol Life Sci
January 2025
Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Unitat de Farmacologia, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028, Barcelona, Spain.
Nuclear growth differentiation factor 15 (GDF15) reduces the binding of the mothers' against decapentaplegic homolog (SMAD) complex to its DNA-binding elements. However, the stimuli that control this process are unknown. Here, we examined whether saturated fatty acids (FA), particularly palmitate, regulate nuclear GDF15 levels and the activation of the SMAD3 pathway in human skeletal myotubes and mouse skeletal muscle, where most insulin-stimulated glucose use occurs in the whole organism.
View Article and Find Full Text PDFEffects of described demonstrator ability on brain and behavior when learning from others.
NPJ Sci Learn
January 2025
Division of Psychology, Karolinska Institutet, Solna, Sweden.
Observational learning enables us to make decisions by watching others' behaviors. The quality of such learning depends on the abilities of those we observe, but also on our beliefs about those abilities. We have previously demonstrated that observers learned better from demonstrators described as high vs.
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