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Identification of a circulating carbohydrate antigen as a highly specific and sensitive target for schistosomiasis serology.
J Clin Microbiol
January 2025
Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Unlabelled: The World Health Organization (WHO) 2030 roadmap for schistosomiasis calls for development of highly sensitive and specific diagnostic tools to continue and sustain progress towards elimination. Serological assays are excellent for sensitive detection of primary schistosome infections and for schistosomiasis surveillance in near- and post-elimination settings. To develop accurate assay formats, it is necessary to identify defined antibody targets with low cross-reactivity and potential for standardized production.
View Article and Find Full Text PDFLandscape of B lymphocytes and plasma cells in digestive tract carcinomas.
Ann Gastroenterol
December 2024
2 Department of Pathology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Greece (Periklis G. Foukas).
Digestive tract carcinomas are the most commonly occurring cancers worldwide, but their prognosis with traditional treatments remains poor. T lymphocytes are well-recognized as crucial components of effective anti-tumor immunity, and current immunotherapeutic strategies concentrate mainly on T-cell-mediated immunity reinforcement, whereas the role of B lymphocytes and plasma cells (PCs) has been neglected in the past, and it is only recently that these cells have been considered as key players in the tumor microenvironment (TME). In this review, we describe the complex dual role of B lymphocytes and PCs in promoting and inhibiting tumor progression in the TME of digestive tract carcinomas, and we demonstrate their prognostic value.
View Article and Find Full Text PDFScorpionism in the State of Bahia, Brazil: A More Neglected Problem During the Pandemic?
Wilderness Environ Med
January 2025
Centro de Ciências Agrárias, Ambientais e Biológicas, Federal University of Recôncavo da Bahia, Cruz das Almas, Brazil.
Introduction: During the confinement in the COVID-19 pandemic, there was an increase in the production of urban waste, increasing the risk of accidents caused by scorpions. We sought to determine the clinical and epidemiologic aspects of scorpionism records in the 7 mesoregions of the State of Bahia, Brazil, examining differences in periods before and during the pandemic.
Methods: Data were obtained from SINAN, Brazil's Notifiable Diseases Information System (January 2010-December 2021).
Ethnic and racial discrimination in maternal health care in Mexico: a neglected challenge in the search for universal health coverage.
Int J Equity Health
January 2025
Center for Health Equity in Latin America, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, Louisiana, USA.
Background: Ethnic and racial discrimination in maternal health care has been overlooked in academic literature and yet it is critical for achieving universal health coverage (UHC). There is a lack of empirical evidence on its impact on the effective coverage of maternal health interventions (ECMH) for Indigenous women in Mexico. Documenting progress in reducing maternal health inequities, particularly given the disproportionate impact of the Covid-19 pandemic on ethnic minorities, is essential to improving equity in health systems.
View Article and Find Full Text PDFSialic Acid-Modified nanomedicines modulate neutrophils for dual therapy of cancer and sepsis: Addressing neglected sepsis comorbidities during cancer treatment.
Int J Pharm
January 2025
College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. Electronic address:
Advanced cancer patients face a high risk of sepsis due to immune suppression and infection susceptibility. To tackle this challenge, we developed an innovative animal model that simulates the clinical scenario of late-stage cancer complicated by sepsis and designed a sialic acid (SA)-modified paclitaxel (PTX) liposome (PTX-SAL). This formulation specifically targets overactivated peripheral blood neutrophils (PBNs) by binding to L-selectin on their surface.
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