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Development and validation of a search strategy and an automated classifier for retrieving temporomandibular disorders studies.
J Oral Facial Pain Headache
June 2024
Orofacial Pain & TMD Program, Faculty of Odontology, Andres Bello University, 8370133 Santiago, Chile.
The objective was to develop and evaluate a comprehensive search strategy (SS) and automated classifier (AC) for retrieving temporomandibular disorders (TMD) research articles. An initial version of SS and AC was created by compiling terms from various sources, including previous systematic reviews (SRs) and consulting with TMD specialists. Performance was assessed using the relative recall (RR) method against a sample of all the primary studies (PS) included in 100 TMD-related SRs, with RR calculated for both SS and AC based on their ability to capture/classify TMD PSs.
View Article and Find Full Text PDFImpact of metabolic-associated fatty liver disease on the cholesterol efflux capacity of high-density lipoproteins in adolescents with type 2 diabetes.
Front Pediatr
December 2024
Department of Endocrinology, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
Context: Type 2 diabetes (DM2) is an emerging disease in the pediatric population. DM2 is associated with metabolic-associated fatty liver disease (MAFLD). High-density lipoproteins (HDLs) are lipoproteins that are believed to have atheroprotective properties that reduce the risk of cardiovascular disease (CVD).
View Article and Find Full Text PDFClinical research framework proposal for ketogenic metabolic therapy in glioblastoma.
BMC Med
December 2024
Biology Department, Boston College, Chestnut Hill, MA, 02467, USA.
Article Synopsis
- Glioblastoma (GBM) is the deadliest brain tumor in adults, and current therapies are largely ineffective, which drives the need for new treatment strategies based on the tumor's metabolic needs, specifically glucose and glutamine.
- A ketogenic metabolic therapy (KMT) approach targets these metabolic pathways by combining dietary changes with specific drugs to limit glycolysis and glutaminolysis, while promoting the use of non-fermentable fuels like ketones and fatty acids.
- The glucose-ketone index (GKI) serves as a biomarker to monitor treatment effectiveness, aiming to create a more hostile environment for tumor growth and improve outcomes in GBM as well as potentially other cancer types reliant on similar metabolic pathways.
Utilization and Evaluation of Ethics Consultation Services in Neonatal Intensive Care.
Children (Basel)
November 2024
Ethics in Medicine Unit, Department of Human Medicine, Philipps University of Marburg, 35037 Marburg, Germany.
Background: The opportunities of perinatal medicine have improved, but this has also been accompanied by increasing ethical challenges. Clinical ethics consultation services (CEC) could support medical teams facing these. However, nothing is currently known about the availability, utilization and evaluation of CEC in German neonatology units.
View Article and Find Full Text PDFACTION-ARC Pediatric and Adult Congenital Heart Disease Ventricular Assist Device Adverse Event Definitions-2023.
ASAIO J
November 2024
Division of Cardiology, Stanford University School of Medicine, Palo Alto, California.
Adverse events (AEs) experienced by children and adults with congenital heart disease (CHD) on ventricular assist devices (VADs) are sometimes unique to these populations. The Advanced Cardiac Therapies Improving Outcomes Network (ACTION) and the Academic Research Consortium (ARC) aimed to harmonize definitions of pediatric and CHD AEs for use in clinical trials, registries, and regulatory evaluation. Data from the ACTION registry and adjudication committee were used to adapt general mechanical circulatory support ARC definitions.
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