A highly chemoselective PPh(3)-catalyzed three-component reaction of an imine, alkyl vinyl ketone, and phthalimide or succinimide is developed. Various highly functional adducts with high diastereoselectivities can be generated via aza-Morita-Baylis-Hillman reactions of aryl-substituted imines and alkyl vinyl ketones followed by Michael additions of imides and then epimerization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo102143r | DOI Listing |
Publication Analysis
Top Keywords
alkyl vinyl
12
three-component reaction
8
reaction imine
8
imine alkyl
8
vinyl ketone
8
organocatalytic tandem
4
tandem three-component
4
ketone imide
4
imide aza-baylis-hillman
4
aza-baylis-hillman reaction
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!