The paper deals with the parallel examination of the resistance of intestinal bacteria and staphylococci to mercury and with testing for the presence of mercury in the basic constituents of the living environment. The results confirm that it is possible to use tests of bacterial resistance as a bioindicator of the contamination of the living environment with mercury.
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Forensic Sci Int Genet
January 2025
School of Forensic Medicine, China Medical University, Shenyang 110000, PR China; Key Laboratory of Forensic Bio-evidence Sciences, Shenyang, Liaoning Province 110000, PR China; China Medical University Center of Forensic Investigation, Shenyang 110000, PR China. Electronic address:
It is challenging to distinguish monozygotic (MZ) twins using traditional autosomal STR genotyping due to their nearly identical genomes. As an important kind of small non-coding RNAs, microRNAs (miRNAs) are essential regulators of gene expression and considered as excellent biomarkers due to their resistance to degradation. Moreover, droplet digital PCR (ddPCR) has emerged as a powerful technique for detecting gene mutations and pathogenic microorganisms, owing to its sensitivity and reliability.
View Article and Find Full Text PDFDiscov Oncol
January 2025
West China School of Medicine, Sichuan University, Chengdu, China.
Gastric cancer is an aggressive malignancy characterized by significant clinical heterogeneity arising from complex genetic and environmental interactions. This study employed single-cell RNA sequencing, using the 10 × Genomics platform, to analyze 262,532 cells from gastric cancer samples, identifying 32 distinct clusters and 10 major cell types, including immune cells (e.g.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates.
Type 2 diabetes (T2D) is a heterogeneous disease influenced by both genetic and environmental factors. Recent studies suggest that T2D subtypes may exhibit distinct gene expression profiles. In this study, we aimed to identify T2D cluster-specific miRNA expression signatures for the previously reported five clinical subtypes that characterize the underlying pathophysiology of long-standing T2D: severe insulin-resistant diabetes (SIRD), severe insulin-deficient diabetes (SIDD), mild age-related diabetes (MARD), mild obesity-related diabetes (MOD), and mild early-onset diabetes (MEOD).
View Article and Find Full Text PDFBiomarkers
January 2025
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Division of Emergency Medicine, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany.
Background: Testing for (SA) colonization in emergency department (ED) patients may guide prevention strategies against hospital acquired infections (HAI). This study determined the prevalence of SA carriers in a general ED population, characterized the population, and identified predictors for SA colonization.
Methods: A prospective monocentric observational cohort study in a tertiary care hospital collected nasopharyngeal swabs in 1,000 adult patients.
BMC Cardiovasc Disord
January 2025
Department of Epidemiology, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, School of Public Health, Nanjing Medical University, 101 Longmian Ave., Nanjing, 211166, China.
Context: The triglyceride-glucose (TyG) index, a novel health indicator, has been widely employed to assess insulin resistance (IR). However, its relationship with fine particulate matter (PM) exposure remains inadequately investigated.
Objective: This study endeavors to probe the association between PM and TyG within the population of eastern China and to determine whether there are disparities in this association among diverse subgroups.
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