For 244 patients with bacteremia due to extended-spectrum β-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae treated by ertapenem (73, 29.9%) or either imipenem or meropenem (171, 70.1%), the therapeutic efficacy was evaluated. Ertapenem therapy was effective for patients with ESBL-producing E. coli or K. pneumoniae bacteremia in terms of mortality and microbiological responses, as compared with imipenem or meropenem.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.diagmicrobio.2010.12.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A case of fatal disseminated infection with masticator space abscess caused by ESBL-producing K57-ST412 hypervirulent Klebsiella pneumoniae.
J Infect Chemother
December 2024
Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
A 70-year-old Japanese man with well-controlled diabetes mellitus and chronic kidney disease was hospitalized for an examination of acute renal failure and elevated inflammatory reactions. He had a history of Klebsiella pneumoniae bacteremia without extended-spectrum β-lactamase (ESBL) production five months earlier. The patient was found to have bacteremia due to hypermucoviscous ESBL-producing Klebsiella pneumoniae, and developed septic shock, multiple cerebral infarctions, and an abscess in the left masticatory muscle space.
View Article and Find Full Text PDFComprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure.
J Infect Dis
November 2024
Department of Infectious Diseases and Infection Control, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background: It remains unclear how high-risk Escherichia coli lineages, like sequence type (ST) 131, initially adapt to carbapenem exposure in their progression to carbapenem resistance.
Methods: Carbapenem mutation frequency was measured in multiple subclades of extended-spectrum β-lactamase (ESBL) positive ST131 clinical isolates using a fluctuation assay followed by whole genome sequencing (WGS) characterization. Genomic, transcriptomic, and porin analyses of ST131 C2/H30Rx isolate, MB1860, under prolonged, increasing carbapenem exposure was performed using two experimental evolutionary platforms to measure fast vs.
Effects of Prospective Audit and Feedback in Patients with Extended-Spectrum -Lactamase-Producing Bacteremia.
Microorganisms
November 2024
Department of Pharmacy, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Antimicrobial stewardship (AS) Guidelines by the Infectious Diseases Society of America recommend employing prospective audit and feedback (PAF) as an effective intervention in AS programs. Since July 2022, our hospital has implemented PAF for all patients with positive blood cultures, including those with extended-spectrum -lactamase (ESBL)-producing (EC) bacteremia. Our study examined the effect of PAF on clinical outcomes in patients with ESBL-EC bacteremia.
View Article and Find Full Text PDFGenomic and growth fitness study of extended-spectrum β-lactamase-producing Escherichia coli from bloodstream infections after introduction of a national 4C antimicrobial stewardship policy in Scotland.
Int J Antimicrob Agents
December 2024
School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen, UK. Electronic address:
Article Synopsis
- Extended spectrum β-lactamase-producing Escherichia coli is a significant cause of hospital-acquired bloodstream infections, particularly in regions with effective antimicrobial management.
- A study at a tertiary hospital in North-East Scotland analyzed bloodstream infection isolates from 2010 to 2020 to assess their genetic structure and resistance patterns after implementing a new antimicrobial stewardship policy called "4C."
- The results revealed that while ST131 E. coli showed a stable presence and reduced resistance over time, its overall fitness declined, suggesting changes in bacterial behavior despite similar virulence factor levels.
Prevalence and clinical significance of the genotypic carriage among ESBL phenotype-negative and clinical isolates in bacteremia: a study in a Malaysian tertiary center.
Front Cell Infect Microbiol
November 2024
Pharmacoepidemiology and Drug Safety Unit, Department of Pharmacology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
Article Synopsis
- Antimicrobial resistance (AMR) poses serious health risks, particularly in bacteria carrying Extended-Spectrum β-Lactamases (ESBL), which can lead to ineffective treatments and increased spread of resistance.
- A study analyzing 137 blood cultures from patients in a Malaysian hospital found that while many bacteria had genotypes linked to ESBL, over half remained susceptible to certain antibiotics, indicating complexities in treating infections.
- Results showed that even though the prediction for ESBL phenotypes was reasonably accurate, there were no significant differences in clinical outcomes, such as severity of infection or mortality, between patients with ESBL-positive and those without.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!