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Among the extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli, 3.9% of K. pneumoniae showed nonsusceptibility to imipenem or meropenem; and their mechanism was the combination of ESBL and/or plasmid-mediated AmpC β-lactamase production and porin loss. The presence of bla(CTX-M-14) and loss of OmpK36 were associated with higher carbapenem MICs.

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http://dx.doi.org/10.1016/j.diagmicrobio.2010.12.012DOI Listing

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