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Does Proprioception-Based Rehabilitation Enhance Functional Outcome in Total Knee Arthroplasty? A Prospective Randomised Study.
Indian J Orthop
October 2024
Ortho-One Orthopaedic Speciality Centre, Coimbatore, Tamil Nadu 641005 India.
Introduction: Rehabilitation after Total Knee Arthroplasty (TKA) often includes proprioceptive exercises to prevent falls, but studies on proprioceptive training have yielded conflicting findings. This study aims to explore impact of proprioceptive training on functional performance after TKA.
Methods: Eighty patients who underwent unilateral TKA were randomly assigned to a proprioceptive exercise (PE) group or a routine exercises (RE) group.
Long-Term Efficacy Following Intra-articular Injection of Carboxymethyl-chitosan, a New Product Class for Knee Osteoarthritis: Results from an Observational Study in Germany.
Rheumatol Ther
June 2024
KiOmed Pharma, 4 rue Haute Claire, 4040, Herstal, Belgium.
Introduction: Evaluate the real-world efficacy of a single intra-articular injection of carboxymethyl-chitosan (CM-chitosan), a new product class for knee osteoarthritis (OA).
Methods: This post-marketing study included adult patients with knee OA, who received a single injection of 60 mg CM-chitosan (currently marketed as KioMedineone) according to the instructions for use. Follow-up was performed at weeks 1, 12, 24, and 36.
Long term improvement of knee osteoarthritis after injection of single high/very high volume of very pure PRP: A retrospective analysis of patients optimally managed in dedicated centers.
Regen Ther
March 2024
Regenerative Medicine Department of Excellence, Marseille, France.
Introduction: PRP is gaining increasing interest for pain relief and improvement of joint function in patients with knee osteoarthritis (KOA) but practices and results remain heterogeneous limiting its adoption as standard of care. Current international recommendations are to collect real-life evidence of efficacy with a systematic monitoring of PRP quality and patients' outcomes. We aimed to analyze the response of patients presenting KOA and treated with standardized PRP injection in routine care.
View Article and Find Full Text PDFExercise therapy for knee osteoarthritis pain: how does it work? A study protocol for a randomised controlled trial.
BMJ Open
January 2024
Gerontology and Frailty in Ageing (FRIA) Research Department, Vrije Universiteit Brussel, Brussel, Belgium.
Article Synopsis
- The study compares the effects of muscle strengthening training (MST) and behavioral graded activity (BGA) on pain relief for patients with knee osteoarthritis (KOA), focusing on inflammation and central sensitization as potential mechanisms.
- It involves a three-arm clinical trial with 90 patients randomly assigned to either MST, BGA, or usual care, with assessments conducted at various intervals over 52 weeks.
- The research seeks to clarify how these exercise therapies might reduce pain, aiming to benefit both scientific understanding and practical applications in pain management and exercise immunology.
Metformin for knee osteoarthritis with obesity: study protocol for a randomised, double-blind, placebo-controlled trial.
BMJ Open
December 2023
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia
Introduction: Over half of the populations with knee osteoarthritis (OA) have obesity. These individuals have many other shared metabolic risk factors. Metformin is a safe, inexpensive, well-tolerated drug that has pleiotropic effects, including structural protection, anti-inflammatory and analgesic effects in OA, specifically the knee.
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