[Myogenic tone of blood vessels in health and disease: role of purinergic signaling system and Na+, K+ 2Cl+ cotransport].

The narrowing of blood vessels evoked by increasing intraluminal pressure and termed as myogenic response plays a key role in the maintenance of the blood flow rate independently of the variation of systemic arterial pressure. Myogenic response MR is accompanied by decreased electrical membrane potential in the vascular smooth muscle cells (VSMC) that, in turn, leads to activation of voltage-gated Ca2+ channels and elevation of [Ca2+]i. Upstream mechanisms underlying VSMC depolarization remain poorly understood. In this review, we summarized data obtained in our laboratories and by other researchers showing tissue-specific impact of purinergic signaling system and Na+, K+, 2Cl- cotransport in the development of myogenic responses along microcirculation.