Cytologic investigation was performed in patients with dacryocystitis after microscopic endonasal dacryocystorhinostomy and in patients with lacrimal canaliculi orifice obstruction after microscopic endonasal canaliculocystorhinostomy. It allowed to monitor healing process, extubation time and to develop measures for prevention of dacryostoma cicatrisation.
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Investigating resistance to 5-Azacytidine and Venetoclax in PDX models of MDS/AML.
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BIOCEV, First Faculty of Medicine, Charles University, Prague, Czechia.
Introduction: Progressing myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) is an indication for hypomethylating therapy (HMA, 5-Azacytidine (AZA)) and a BCL2 inhibitor (Venetoclax, VEN) for intensive chemotherapy ineligible patients. Mouse models that engraft primary AML samples may further advance VEN + AZA resistance research.
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Performance of artificial intelligence for diagnosing cervical intraepithelial neoplasia and cervical cancer: a systematic review and meta-analysis.
EClinicalMedicine
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View Article and Find Full Text PDFUnmasking the potential: a historical perspective on the evolution of exfoliative cytology in oral cavity neoplasms.
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Department of Biomedical and Dental Sciences, Morphological and Functional Images, G. Martino University Hospital, University of Messina, Messina, Italy.
Exfoliative cytology has proven to be a valuable diagnostic tool in the early detection of malignant neoplasms. However, its application in the oral cavity has been met with skepticism and limited investigation due to the perception that clinical examination alone is sufficient for early diagnosis. Nonetheless, recent research efforts have focused on the utility of exfoliative cytology in oral cavity neoplasms, motivated by the high mortality rate associated with oral cancer.
View Article and Find Full Text PDFThyroid cancer and Hashimoto's thyroiditis in AUS/FLUS nodules: is there a correlation? A retrospective study.
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Gastric cancer is a prevalent gastrointestinal tumor. In the classical cascade of gastric cancer development, the gradual progression from non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, to intraepithelial neoplasia eventually leads to early gastric cancer. We investigated the proteomic characteristics of chronic gastritis (CG), low-grade intraepithelial neoplasia (low-grade LGIN), and early gastric cancer (EGC).
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