Purpose: To demonstrate that the Landers wide-field temporary keratoprosthesis (TKP) creates a watertight seal between the tightly opposing surfaces of the TKP flange and the anterior corneal surface.
Methods: In 25 and 20 enucleated, porcine eyes, a 7.5-mm and 8.0-mm trephination corneal hole was made, respectively, followed by open-sky capsulorhexis and lensectomy. A wide-field TKP with 7.2 mm trunk diameter was sutured securely onto each eye. Testing for a watertight seal was performed at an intraocular pressure of 100 mmHg of pre- and post-pars plana vitrectomy.
Results: The Landers TKP maintained a watertight seal at an intraocular pressure of 100 mmHg in 45 of 45 eyes. After standard pars plana vitrectomy, 41 of 41 eyes maintained 100 mmHg of intraocular pressure without leakage.
Conclusion: The seal between the TKP and cornea is established at the horizontal interface between the TKP flange and the anterior corneal surface, not between the corneal stroma and TKP trunk. The Landers wide-field TKP is a reusable model that provides a clear posterior-segment view and effectively forms a watertight eye at a sustained intraocular pressure of 100 mmHg. This TKP may be used in ocular trauma where the corneal defect is up to 0.8 mm greater in diameter than the 7.2-mm TKP trunk.
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http://dx.doi.org/10.1097/IAE.0b013e318203c16e | DOI Listing |
Jpn J Ophthalmol
January 2025
Department of Ophthalmology, Graduate of Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Purpose: To assess the efficacy and safety of PreserFlo MicroShunt (PMS) combined with mitomycin C in patients with medically treated primary open-angle glaucoma (POAG).
Study Design: A retrospective observational study.
Methods: The study examined 83 eyes from 83 patients with medically treated glaucoma surgery naive POAG.
BMC Ophthalmol
January 2025
Department of Ophthalmology, Medical Faculty, University Hospital of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Background/ Aims: To analyze the longitudinal change in Bruch's membrane opening minimal rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (pRNFL) thickness using optical coherence tomography (OCT) after implantation of a PRESERFLO® microshunt for surgical glaucoma management in adult glaucoma patients.
Methods: Retrospective data analysis of 59 eyes of 59 participants undergoing implantation of a PRESERFLO microshunt between 2019 and 2022 at a tertiary center for glaucoma management. Surgical management included primary temporary occlusion of the glaucoma shunt to prevent early hypotony.
Am J Ophthalmol Case Rep
December 2024
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Purpose: To report a case of corneoscleral juvenile xanthogranuloma (JXG) with progressive anterior segment involvement refractory to topical steroids.
Observations: A 4-month-old male was referred for a new-onset subconjunctival lesion in the right eye. He was found to have a thickened, yellow corneoscleral lesion and hyphema, presumed to be ocular JXG.
Transl Vis Sci Technol
January 2025
Medical School of Chinese People's Liberation Army, Beijing, China.
Purpose: The purpose of this study was to evaluate the correlation between axial length (AL) and retinal oxygen dynamic parameters in adult patients.
Methods: This was an observational cross-sectional study with 79 Chinese adults with myopia aged 18 to 37 years. All participants underwent AL measurements, cycloplegic refraction, and other ophthalmic examinations.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai Hospital, New York, New York, United States.
Purpose: Vascular impairments, including reduced capillary density (CD), impaired autoregulation capacity (Reg), and elevated intraocular pressure (IOP), have been identified as significant contributors to glaucomatous disease. This study implemented a theoretical model to quantify the impact of these impairments on retinal blood flow and oxygenation as intraluminal pressure (Pa) is varied.
Methods: A theoretical model of the retinal vasculature was used to simulate reductions in CD by 10% (early glaucoma) and 30% to 50% (advanced glaucoma), a range in autoregulation capacity from 0% (totally impaired) to 100% (totally functional), and normal (15 mm Hg) and elevated (25 mm Hg) levels of IOP.
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