AI Article Synopsis
- The study examined how polyphenolic compounds in red wine from Vale do São Francisco cause blood vessel relaxation.
- Red wine induced significant relaxation in mesenteric artery rings, but this effect was reduced when the endothelium was removed or when specific inhibitors were used, showing the importance of the endothelium and certain pathways.
- Increased nitric oxide levels in rabbit aortic endothelial cells were observed with higher concentrations of red wine, suggesting that the vasorelaxant effects are linked to nitric oxide production and the phenolic compounds present in red wine.
Article Abstract
The aim of this study was to investigate the mechanisms underlying the vasorelaxant effect induced by the polyphenolic compounds found in red wine from Vale do São Francisco. In phenylephrine (10 μM) precontracted mesenteric artery rings, the red wine caused a concentration-dependent relaxation (maximum response to phenylephrine 10 μM = 87.5% ± 6.5%, n = 10). After endothelium removal, the vasorelaxant effect elicited by red wine was attenuated (28.4% ± 4.9%, n = 10). In addition, the vasorelaxant effect induced by red wine in rings pretreated with 100 μM of N(w)-nitro-l-arginine methyl ester and 10 μM of 1H-[1,2,4] oxadiazolo-[4,3-a]-quinoxalin-1-one was attenuated (23.4% ± 5.1%, n = 7 and 11.8% ± 2.7%, n = 6, respectively). Pretreatment with atropine did not affect the vasorelaxant effect induced by red wine (81% ± 3.9%, n = 6). Furthermore, in rabbit aortic endothelial cell line, red wine 100 and 300 μg/mL caused concentration-dependent increases in nitric oxide levels (58 ± 1; 82 ± 7.9; Δ% of fluorescence, n = 5, respectively). In conclusion, we suggest that the alcohol free-lyophilized red wine induces an endothelium-dependent vasorelaxant effect due, at least in part, to a secondary increase in the concentration of nitric oxide and that this effect might be associated with phenolic compounds found in the red wine.
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| http://dx.doi.org/10.1097/FJC.0b013e318217db1f | DOI Listing |
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