AI Article Synopsis
- - The discovery of JAK2 mutations has sparked renewed interest in diagnosing and treating myeloproliferative neoplasms (MPNs) that are negative for BCR/ABL, emphasizing the importance of additional clinical and laboratory parameters.
- - Diagnosis and subclassification of MPNs are crucial, even in cases where the JAK2 V617F mutation is absent.
- - Two cases of patients with splenomegaly and moderate leukocytosis were diagnosed as primary myelofibrosis (PMF) in the prefibrotic phase and polycythemia vera (PV) using the revised WHO 2008 criteria.
Article Abstract
The recent discovery of the JAK2 mutations has rekindled interest in the approach to classic BCR/ABL-negative myeloproliferative neoplasms (MPNs) in terms of both diagnostic evaluation and treatment. However, additional clinical, laboratory and histological parameters play a key role to allow diagnosis and subclassification, regardless of whether JAK2 V617F mutation is present or not. Here are two cases which incidentally presented with splenomegaly and moderate leukocytosis, and were diagnosed as MPN-primary myelofibrosis (PMF) in prefibrotic phase and polycythemia vera (PV), respectively, using revised World Health Organization (WHO) 2008 criteria.
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| http://dx.doi.org/10.4103/0377-4929.77355 | DOI Listing |
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