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Subspecies Endocarditis and Meningitis in a 62-Year-Old Horse Rider Patient: A Case Report and Literature Review.
Microorganisms
October 2024
Department of Infectious Diseases, Azienda Ospedaliera-Universitaria of Modena, University of Modena and Reggio Emilia, 41125 Modena, Italy.
The present article presents a case report and literature review concerning the subspecies (SEZ), a rare zoonotic pathogen in humans. The case involves a 62-year-old man with no prior heart disease, presenting with endocarditis, pneumonia, and meningitis following close contact with a horse. The patient underwent urgent aortic valve replacement due to severe valvular damage caused by the infection.
View Article and Find Full Text PDFThe antibiotic therapy containing contezolid successfully treated methicillin-sensitive Staphylococcus aureus infective endocarditis accompanied with cerebrovascular complications.
BMC Infect Dis
November 2024
Department of Respiration and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, P.R. China.
Background: Staphylococcus aureus infective endocarditis (IE) in native valves is associated with high mortality rates and is prone to various complications, including embolic strokes, which often result in poor prognoses. Contezolid, a novel oxazolidinone antibiotic, exhibits superior therapeutic efficacy with a reduced risk of hematologic toxicity. However, there are currently no reports on the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) IE accompanied by cerebrovascular complications.
View Article and Find Full Text PDFBactericidal versus bacteriostatic antibacterials: clinical significance, differences and synergistic potential in clinical practice.
J Antimicrob Chemother
January 2025
School of Medicine, European University Cyprus, 6 Diogenes str, Nicosia 2404, Cyprus.
Antibacterial activity can be classified as either bactericidal or bacteriostatic, using methods such as the MBC/MIC ratio and time-kill curves. However, such categorization has proven challenging in clinical practice, as these definitions only apply under specific laboratory conditions, which may differ from clinical settings. Several factors, such as the specific bacteria or infectious medium, can affect the action of antibiotics, with many antibacterials exerting both activities.
View Article and Find Full Text PDFErysipelothrix rhusiopathiae bacteremia treated with linezolid.
J Infect Chemother
September 2024
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:
Article Synopsis
- * A case of a 60-year-old woman is presented who developed E. rhusiopathiae bacteremia after injuring her leg in a sewer, with no clear animal contact, suggesting sewage as the source.
- * She improved after being treated with intravenous penicillin, but due to her circumstances, she was switched to an oral antibiotic, linezolid, which was successful, highlighting the bacteria's resistance to vancomycin and limited alternatives for treatment.
Clinical characteristics and analysis of prognostic factors in methicillin-resistant Staphylococcus aureus endocarditis: A retrospective multicenter study in Japan.
J Infect Chemother
December 2024
Division of Clinical Infectious Diseases, School of Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.
Background: Infective endocarditis (IE) caused by MRSA (methicillin-resistant Staphylococcus aureus) is associated with a high mortality rate. This study aimed to elucidate the characteristics of patients with MRSA-IE in Japan and identify the factors associated with prognosis.
Methods: This retrospective study included patients with a confirmed diagnosis of IE caused by MRSA, between January 2015 and April 2019.
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