Background: Over-use of antibiotics for acute respiratory infections (ARIs) increases antimicrobial resistance, treatment costs, and side effects. Patient desire for antibiotics contributes to over-use.
Objective: To explore whether a point-of-care interactive computerized education module increases patient knowledge and decreases desire for antibiotics.
Methods: Bilingual (English/Spanish) interactive kiosks were available in 8 emergency departments as part of a multidimensional intervention to reduce antibiotic prescribing for ARIs. The symptom-tailored module included assessment of symptoms, knowledge about ARIs (3 items), and desire for antibiotics on a 10-point visual analog scale. Multivariable analysis assessed predictors of change in desire for antibiotics.
Results: Of 686 adults with ARI symptoms, 63% initially thought antibiotics might help. The proportion of patients with low (1-3 on the scale) desire for antibiotics increased from 22% pre-module to 49% post-module (p<.001). Self-report of "learning something new" was associated with decreased desire for antibiotics, after adjusting for baseline characteristics (p=.001).
Conclusion: An interactive educational kiosk improved knowledge about antibiotics and ARIs. Learning correlated with changes in personal desire for antibiotics.
Practice Implications: By reducing desire for antibiotics, point-of-care interactive educational computer technology may help decrease inappropriate use for antibiotics for ARIs.
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http://dx.doi.org/10.1016/j.pec.2011.02.005 | DOI Listing |
Int J Biol Macromol
January 2025
Department of Mechanical Engineering, Faculty of Engineering, Xi'an Technological University, Shaanxi, China. Electronic address:
This study explored the use of mango lignocellulosic kernel biochar (MKB) modified with MnFeO magnetic nanoparticles and a Cu@Zn-BDC metal-organic framework (MOF) (MKB/MnFeO/Cu@Zn-BDC MOF) for tetracycline (TC) removal from aqueous solutions and hospital wastewater. The modified biochar exhibited strong magnetic properties (19.803 emu/g) and a specific surface area of 30.
View Article and Find Full Text PDFMolecules
December 2024
Postgraduate Program in Amazonian Natural Resources Engineering, Federal University of Pará, Rua Augusto Correa, 01, Belém 66075-110, Brazil.
The widespread use of antibiotics such as fluoroquinolones (FQs) has raised environmental and health concerns. This study is innovative as we investigate the removal of ciprofloxacin (CIP) and norfloxacin (NOR) from water using activated carbon derived from cupuaçu bark (CAC). This previously discarded biomass is now a low-cost raw material for the production of activated carbon, boosting the local economy.
View Article and Find Full Text PDFDrug Des Devel Ther
December 2024
Department of Pharmaceutical Technology, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Purpose: Nitrofurantoin (NITRO), a long-standing antibiotic to treat urinary tract infections, is activated by Nitro reductases. This activation mechanism has led to its exploration for repositioning applications in controlling and treating breast cancer, which express a Nitro reductase gene.
Methods: NITRO Cubosomes were developed using hot homogenization according to 2-full factorial design.
JAMA Netw Open
December 2024
School of Pharmacy, University of Maryland, Baltimore.
Importance: Initiating effective therapy early is associated with improved survival among patients hospitalized with gram-negative bloodstream infections; furthermore, providing early phenotype-desirable antimicrobial therapy (PDAT; defined as receipt of a β-lactam antibiotic with the narrowest spectrum of activity to effectively treat the pathogen's phenotype) is crucial for antimicrobial stewardship. However, the timing of targeted therapy among patients hospitalized with gram-negative bloodstream infections is not well understood.
Objective: To compare the clinical outcomes between patients who were hospitalized with Enterobacterales bloodstream infections receiving early vs delayed PDAT.
Infect Dis (Lond)
December 2024
Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Spain.
Purpose: A analysis of data from a previously published clinical trial was conducted using the desirability of outcome ranking (DOOR) methodology with the aim provide additional information on the use of fosfomycin for the treatment of bacteraemic urinary tract infection (BUTI) caused by multi-drug-resistant (MDR) .
Methods: Three DOOR systems with five, six and seven categories, respectively were developed. Safety and efficacy were prioritised in all rankings, but step down to oral therapy and exposure to antibiotics with lower ecological impact were also considered in DOOR-6 and DOOR-7.
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