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Microbiology and risk factors for bacteremic urinary tract infection: insights from the largest urological center in Pakistan.
Int Urol Nephrol
December 2024
Department of Infectious Diseases, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.
Background: Bacteremic urinary tract infections (bUTI) are associated with significant morbidity and mortality. This study aims to identify risk factors, pathogenic organisms, and resistance patterns in bUTI.
Methods: This prospective cohort study was conducted at a tertiary care urology center.
alkyl quinolone response is dampened by .
mBio
December 2024
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Unlabelled: The bacterium is an opportunistic pathogen that can cause lung, skin, wound, joint, urinary tract, and eye infections. While is known to exhibit a robust competitive response toward other bacterial species, this bacterium is frequently identified in polymicrobial infections where multiple species survive. For example, in prosthetic joint infections, can be identified along with other pathogenic bacteria including , , and .
View Article and Find Full Text PDFRisk factors for bacteremia in infants with urinary tract infection.
Pediatr Neonatol
October 2024
Department of Pediatrics, Pingtung Veterans General Hospital, Pingtung, Taiwan; Division of Pediatric Nephrology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Electronic address:
Background: Some infants with urinary tract infection (UTI) may exhibit concurrent bacteremia, potentially leading to septic shock or bacterial meningitis. Identifying risk factors for bacteremia in infants with UTI is crucial for prompt intervention to prevent subsequent adverse outcomes.
Methods: Between 2015 and 2021, a total of 632 infants with UTI aged ≤12 months were enrolled at Kaohsiung Veterans General Hospital (KSVGH), among whom 20 had concurrent bacteremia.
Infection characteristics among capsule lineages.
bioRxiv
August 2024
University of Michigan, Michigan Medicine. Department of Microbiology and Immunology. Ann Arbor, MI U. S. A.
Article Synopsis
- The text discusses a healthcare-associated pathogen that leads to infections in the bloodstream, lungs, and urinary tract, highlighting the importance of its capsule polysaccharide in its ability to cause disease.
- It describes how different capsule genetic sequences (specifically KL1, KL2, and KL5) impact the pathogen’s ability to colonize organs and survive in various infection models, with KL1 and KL2 strains being particularly adept at causing disease.
- The study also finds that the capsule of KL1 and KL2 strains helps resist attack by immune cells (macrophages), which may enhance the pathogen’s survival and ability to spread during infection.
Clinical Outcomes of Patients with AmpC-Beta-Lactamase-Producing Enterobacterales Bacteremia Treated with Carbapenems versus Non-Carbapenem Regimens: A Single-Center Study.
Antibiotics (Basel)
July 2024
Faculty of Medicine, Hebrew University, Jerusalem 91904, Israel.
Introduction: Bloodstream infections caused by AmpC-producing Enterobacterales pose treatment challenges due to the risk of AmpC overproduction and treatment failure. Current guidelines recommend carbapenems or cefepime as optimal therapy. We aimed to evaluate empiric and definitive non-carbapenem regimens for these infections.
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