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Membrane-Targeted Quantum Dot-Based BACE1 Activity Sensors for and Assays.
ACS Appl Mater Interfaces
November 2024
Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, (CIBERNED), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.
The need for the development of specific and robust methodologies to elucidate the intricate pathological mechanisms of neurodegenerative diseases and discover effective treatments for prevention and remediation is evident. Alzheimer's disease, in particular, has become more prevalent as the global population has aged. β-Secretase, the β-site amyloid precursor protein cleaving enzyme (BACE1), is the protease that produces the β-amyloid peptide, which is considered one of the driving factors of Alzheimer's disease and an important target for treatment development.
View Article and Find Full Text PDFA handheld fluorescent platform integrated with a Sm(III)-CdTe quantum dot-based ratiometric nanoprobe for point-of-use determination of phosphate.
Nanoscale
November 2024
College of Civil and Transportation Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China.
Article Synopsis
- Phosphate (Pi) is essential for physiological processes and environmental health, prompting the need for a simple sensor to quickly detect it for health and conservation purposes.
- This study presents a dual-emission ratiometric fluorescence sensor that uses samarium ions and cadmium telluride quantum dots for sensitive Pi detection, indicated by a color change from purple to blue due to fluorescence recovery.
- The developed portable lab-on-paper device allows for quick Pi detection using a smartphone, showing effective performance in environmental and biological samples, which highlights a new approach for affordable and precise target detection.
Quantum Dot-Based FRET Nanosensors for Talin-Membrane Assembly and Mechanosensing.
Angew Chem Int Ed Engl
October 2024
Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.
Understanding the mechanisms of assembly and disassembly of macromolecular structures in cells relies on solving biomolecular interactions. However, those interactions often remain unclear because tools to track molecular dynamics are not sufficiently resolved in time or space. In this study, we present a straightforward method for resolving inter- and intra-molecular interactions in cell adhesive machinery, using quantum dot (QD) based Förster resonance energy transfer (FRET) nanosensors.
View Article and Find Full Text PDFQuantum Material-Based Self-Propelled Microrobots for the Optical "On-the-Fly" Monitoring of DNA.
ACS Appl Mater Interfaces
December 2023
Future Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology (CEITEC-BUT), 61200 Brno, Czech Republic.
Quantum dot-based materials have been found to be excellent platforms for biosensing and bioimaging applications. Herein, self-propelled microrobots made of graphene quantum dots (GQD-MRs) have been synthesized and explored as unconventional dynamic biocarriers toward the optical "on-the-fly" monitoring of DNA. As a first demonstration of applicability, GQD-MRs have been first biofunctionalized with a DNA biomarker (i.
View Article and Find Full Text PDFMethylation-Powered Assembly of a Single Quantum Dot-Based FRET Nanosensor for Antibody-Free and Enzyme-Free Monitoring of Locus-Specific -Methyladenosine in Clinical Tissues.
Anal Chem
December 2023
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
-Methyladenosine (mA) is the most pervasive and evolutionarily conserved epitranscriptomic modification in long noncoding RNA (lncRNA), and its dysregulation may induce aberrant transcription and translation programs. Herein, we demonstrate the methylation-powered assembly of a single quantum dot (QD)-based fluorescence resonance energy transfer (FRET) nanosensor for antibody- and enzyme-free monitoring of locus-specific mA in clinical tissues. The mA-sensitive DNAzyme VMC10 is employed to identify a specific mA site in lncRNA, and it catalyzes the hydrolytic cleavage of unmethylated lncRNA.
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