AI Article Synopsis
- The study aimed to assess vitamin B12 deficiency in Brazilian diabetic patients treated with metformin.
- Out of 144 patients, 6.9% had low vitamin B12 levels, and 36.8% had possibly low levels, with deficiencies linked to older age and longer metformin use.
- Findings indicate a significant risk of vitamin B12 deficiency in these patients, particularly among the elderly and those with inadequate dietary intake of the vitamin.
Article Abstract
Objective: The objective of this study was to evaluate the presence of vitamin B12 deficiency and the factors associated with serum vitamin B12 levels in a sample of metformin-treated Brazilian diabetic patients.
Method: Cross-sectional study.
Results: 144 patients were included. Serum vitamin B12 levels were low (< 125 pmol/L) in 10 patients (6.9%) and possibly low (125 - 250 pmol/L) in 53 patients (36.8%). Serum vitamin B12 levels were negatively associated with age (B = -3.17; β= -0.171; p = 0.037) and duration of metformin use (B= -33.36; β= -0.161; p = 0.048), and positively associated with the estimated intake of vitamin B12 (B= 67.96; β= 0.249; p = 0.002).
Conclusion: The present findings suggest a high prevalence of vitamin B12 deficiency in metformin-treated diabetic patients. Older patients, patients in long term treatment with metformin and low vitamin B12 intake are probably more prone to this deficiency.
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