Anthracene-boronic acid ester as a new class of fluorescence PET sensors for detection of a trace amount of water in organic solvents has been designed and developed.
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http://dx.doi.org/10.1039/c1cc10470e | DOI Listing |
Theranostics
January 2025
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging (CMI), Copenhagen University Hospital, Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Denmark.
: In oral and oropharyngeal squamous cell carcinoma (OSCC, OPSCC), frequent inadequate surgical margins highlight the importance of precise intraoperative identification and delineation of cancerous tissue for improving patient outcomes. : A prospective, open-label, single-center, single dose, exploratory phase II clinical trial (EudraCT 2022-001361-12) to assess the efficacy of the novel uPAR-targeting near-infrared imaging agent, FG001, for intraoperative detection of OSCC and OPSCC. Macroscopic tumor detection was quantified with sensitivity and intraoperative tumor-to-background ratio (TBR).
View Article and Find Full Text PDFBioorg Med Chem
December 2024
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address:
The purinergic P2X ligand-gated ion channel 7 receptor (P2X7R) plays a critical role in various inflammatory processes and other diseases. Fast determination of compounds P2X7R binding potency and discovery of a promise PET radiotracer for imaging P2X7R require a P2X7R suitable radioligand for radioactive competitive binding assay. Herein, we designed and synthesized thirteen new P2X7R ligands and determined the in vitro binding potency.
View Article and Find Full Text PDFTalanta
December 2024
Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, China. Electronic address:
Iron and zinc are two metal ions with important roles in biology, industry and the environment, however, the excess or deficiency of both Fe and Zn can have negative effects on organisms and environment. Therefore, the development of efficient method for simultaneous detection of Fe and Zn provides timely information on metal content, simplifies operations and improves efficiency. In this work, a small molecule (COOH-BPEA) of recognizing Zn modified the four metal-organic-framework (MOF) (UiO-66-X(66, OH, NH and OH/NH)) was developed for the simultaneous detection of Fe and Zn.
View Article and Find Full Text PDFTo realize the aim of easy and accurate detection of ammonia and picric acid (PA) in both aqueous and vapor phases based on function-oriented investigation principles, in the present study, we include a luminescent performance with recognition performance, taking into account the application conditions. Zn(II) ions with luminescence qualities and an amine-substituted imidazole moiety with selective recognition properties towards picric acid and ammonia are coupled to generate a novel 1D luminous Zn(II) coordination polymer, Zn-CP [{Zn(II)( 2-ABZ)2(2-BDC)}].MeOH]∞, where 2-ABZ and 2-BDC stand for terephthalic acid and protonated 2 aminobenzimidazole, respectively.
View Article and Find Full Text PDFACS Sens
December 2024
UNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey.
Diverse analytical techniques are employed to scrutinize microplastics (MPs)─pervasive at hazardous concentrations across diverse sources ranging from water reservoirs to consumable substances. The limitations inherent in existing methods, such as their diminished detection capacities, render them inadequate for analyzing MPs of diminutive dimensions (microplastics: 1-5 μm; nanoplastics: < 1 μm). Consequently, there is an imperative need to devise methodologies that afford improved sensitivity and lower detection limits for analyzing these pollutants.
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