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Background: Circadian function, characterized by circadian strength, timing, and fragmentation, has been shown to correlate with cognitive function; however, little is known about in these associations, particularly among older adults who may have more variability in their sleep-wake schedules.
Method: Among 60 community-living adults aged 60-90 years with self-reported sleep complaints ≥once/ week, we investigated gender differences in the associations between circadian and cognitive function. Participants completed seven days of actigraphy and one night of polysomnography.
Public Health.
Alzheimers Dement
December 2024
College of Nursing, University of Tennessee, Knoxville, TN, USA.
Background: Bi+ people, those with non-monosexual identities (e.g., bisexual, pansexual, sexually fluid) are more likely to experience poor physical and mental health compared with monosexual minority (i.
View Article and Find Full Text PDFBackground: An advantage of blood-based biomarkers of Alzheimer's disease (AD) is that collection is easily repeatable and minimally invasive. Repeated biomarker measurements provide greater sensitivity for detecting within-person change, which in clinical trials can allow for reductions in sample sizes required to detect treatment effects and shorten trial periods. We validated Dried Blood Spots (DBS) as a novel matrix for measuring blood biomarkers of AD, as collection is easily repeatable, less burdensome for participants, and more economical than phlebotomy, and shipment and storage are simplified.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Douglas Mental Health University Institute, Centre for Studies on the Prevention of Alzheimer's Disease (StoP-AD), Montréal, QC, Canada.
Background: Increasing evidence suggests a link between sleep and Alzheimer disease's (AD) pathology and cognitive decline. We investigated whether sleep disturbances might be accompanied by faster AD pathology accumulation and/or cognitive decline before the onset of cognitive symptoms.
Method: We investigated cross-sectional and longitudinal associations between sleep quality, AD pathology and cognition in 220 participants from the PREVENT-AD cohort.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Nevada Las Vegas School of Public Health, Las Vegas, NV, USA.
Background: Our previous work has found that sexual and gender minority (SGM) or LGBTQIA+ caregivers of people living with Alzheimer's disease and related dementias (ADRD) experience higher levels of stigma, depressive symptoms, and stress than non-SGM caregivers and that these outcomes are associated with experiences of microaggressions related to their SGM identities. Guided by the Health Equity Promotion Model, we sought to explore the impact of the environmental context on psychosocial outcomes among SGM caregivers of people living with ADRD.
Methods: Data from a cross-sectional online survey using a non-probabilistic sample of SGM caregivers of people with ADRD recruited via social media (n = 284) were combined with publicly available data reporting composite equity climate index scores across five domains: legal/non-discrimination protections, youth/family support, political/religious attitudes, health access/safety, and work environment/employment.
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