Although a number of studies have focused on the higher ethyl pyruvate antioxidative activity than its sodium salt under various stress conditions, and the greater protective properties of the ester form have been suggested as the effect of better cell membrane penetration, the molecular mechanism has remained unclear. The aim of the present study was therefore to compare the antioxidative activities of sodium and ethyl pyruvate under in vitro conditions by using a liver homogenate as the model for cell membrane transport deletion. The potential effect of ethanol was also evaluated, and hypochlorous acid was used as an oxidant. Our data indicate the concentration-dependent scavenging potency of both sodium and ethyl pyruvate, with the ester having higher activity. This effect was not related to the presence of ethanol. Better protection of the liver homogenate by ethyl pyruvate was also apparent, despite the fact that cell membrane transport was omitted.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1271/bbb.100728 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Renal and Vascular Functional Decline in Aged Low Birth Weight Murine Adults.
Kidney Blood Press Res
December 2024
Department of Medicine, New York Medical College, Valhalla, New York, USA.
Article Synopsis
- Maternal undernutrition leads to low birth weight in neonates, which can increase the risk for high blood pressure and kidney disease later in life, though the exact reasons are not fully understood.
- The study utilized a mouse model to examine factors like oxidative stress and vascular function in low birth weight mice after one year, measuring various health indicators and testing different pharmacological treatments.
- Results showed that low birth weight mice had higher blood pressure and decreased kidney function, but administration of specific drugs improved their conditions, indicating that therapies targeting oxidative stress and vascular function might mitigate some long-term health issues.
Modulation of persistent bladder pain in mice: The role of macrophage migration inhibitory factor, high mobility group box-1, and downstream signaling pathways.
Bladder (San Franc)
October 2024
Lexington VA Health Care System, Research and Development, Lexington, KY, USA.
Background: Repeated intravesical activation of protease-activated receptor-4 (PAR4) serves as a model of persistent bladder hyperalgesia (BHA) in mice, which lasts several days after the final stimulus. Spinal macrophage migration inhibitory factor (MIF) and high mobility group box 1 (HMGB1) are critical mediators in the persistence of BHA.
Objective: We aimed to identify effective systemic treatments for persistent BHA using antagonists or transgenic deletions.
Metabolic-driven analytics of traumatic brain injury and neuroprotection by ethyl pyruvate.
J Neuroinflammation
November 2024
Department of Radiology, Loma Linda University, 11234 Anderson St, Room B623 MRI, Loma Linda, CA, 92354, USA.
Background: Research on traumatic brain injury (TBI) highlights the significance of counteracting its metabolic impact via exogenous fuels to support metabolism and diminish cellular damage. While ethyl pyruvate (EP) treatment shows promise in normalizing cellular metabolism and providing neuroprotection, there is a gap in understanding the precise metabolic pathways involved. Metabolomic analysis of the acute post-injury metabolic effects, with and without EP treatment, aims to deepen our knowledge by identifying and comparing the metabolite profiles, thereby illuminating the injury's effects and EP's therapeutic potential.
View Article and Find Full Text PDFIdentification of altered blood metabolic pathways in equines following ethyl pyruvate administration using non-targeted metabolomics.
Sci Rep
November 2024
Korea Racing Authority, Gwacheon, Republic of Korea.
Ethyl pyruvate (EP) has emerged as a promising compound with potential therapeutic benefits attributed to its anti-inflammatory and antioxidant properties. This study aimed to understand the effects of EP on plasma metabolites and immune cells in horses, utilizing advanced liquid chromatography-mass spectrometry (LC-MS)-based metabolomics, quantitative polymerase chain reaction (qPCR), and blood chemistry analyses. Our comprehensive analysis detected 2,366 ions, and 126 metabolites were accurately identified.
View Article and Find Full Text PDFBiological Properties of KYS-164 Isolated from Kefir Grains.
J Agric Food Chem
November 2024
College of Food Science and Technology, Northwest University, Xi'an, Shaanxi 710069, China.
KYS-164, isolated from homemade Tibetan kefir grains, produces bacteriocin-like inhibitory substances (BLIS), which are peptides with antimicrobial properties, but have not been fully characterized. The research on BLIS will lay the foundation for mining new bacteriocins. In this study, the optimal culture conditions for the production of highly active BLIS were found to be incubation at 30 °C and 120 rpm, and the most effective extraction method was ammonium sulfate precipitation (ASP) using ammonium sulfate at 80% saturation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!