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Noninvasive molecular diagnosis of human visceral leishmaniasis. | LitMetric

Noninvasive molecular diagnosis of human visceral leishmaniasis.

J Clin Microbiol

Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

Published: May 2011

AI Article Synopsis

  • Previously developed noninvasive PCR methods for diagnosing visceral leishmaniasis (VL) have notable limitations.
  • A study tested PCR diagnosis using buccal swabs on 307 subjects, including 148 confirmed VL patients.
  • This method proved to be simple, well-tolerated, and showed promising results with 83% sensitivity and 90.56% specificity.

Article Abstract

Previously developed methods for noninvasive PCR diagnosis of visceral leishmaniasis (VL) have significant limitations. Diagnosis of VL using PCR and buccal swabs was evaluated in 307 subjects, including 148 patients confirmed to have VL. This method is simple and well tolerated and has good potential for development, showing 83% sensitivity with 90.56% specificity in control groups.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122692PMC
http://dx.doi.org/10.1128/JCM.00130-11DOI Listing

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