Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression.

Cytokine Growth Factor Rev

Department for Molecular Biomedical Research, VIB, Ghent, Belgium.

Published: April 2011

The predominant role of matrix metalloproteinase 8 in extracellular matrix turnover, modulation of inflammatory responses and other physiological processes is well documented. Several recent studies highlight the involvement of MMP8 in a wide range of pathologies. This review will shed light on the putative role of MMP8 as a drug target or disease marker in some inflammatory disorders and in cancer progression.

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http://dx.doi.org/10.1016/j.cytogfr.2011.02.002DOI Listing

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