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From Breaking Bad to Breaking Bonds-Mass Spectrometry in the Classroom.
Rapid Commun Mass Spectrom
January 2025
School of Chemical Sciences, University of Hertfordshire, Hatfield, UK.
We describe a workshop that prompts chemistry students in the final 2 years of secondary school to apply their understanding of modern analytical chemistry techniques to a 'real world' example. The scenario used is that of a forensic science laboratory that has been asked to determine the structure of an illicit compound, Revisomed (methamphetamine) being sold as a revision aid, and seized by police. Over the course of an hour, the students use a combination of infrared (IR) spectroscopy, liquid chromatography (LC), high-resolution mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy data to determine the structure of Revisomed from first principles.
View Article and Find Full Text PDFTowards a comprehensive definition of the human fascial system.
J Anat
January 2025
Department of Pathology, New York University Grossman School of Medicine, New York, New York, USA.
The absence of a clear consensus on the definition and significance of fascia and the indiscriminate use of the term throughout the clinical and scientific literature has led to skepticism regarding its importance in the human body. To address this challenge, we propose that: (1) fasciae, and the fascial interstitia within them, constitute an anatomical system, defined as a layered body-wide multiscale network of connective tissue that allows tensional loading and shearing mobility along its interfaces; (2) the fascial system comprises four anatomical organs: the superficial fascia, musculoskeletal (deep) fascia, visceral fascia, and neural fascia; (3) these organs are further composed of anatomical structures, some of which are eponymous; (4) all these fascial organs and their structural components contain variable combinations and arrangements of the four classically defined tissues: epithelial, connective, muscle, and neural; (5) the overarching functions of the fascial system arise from the contrasting biomechanical properties of the two basic types of layers distributed throughout the system: one predominantly collagenous and relatively stiff, the other rich in hyaluronic acid and viscous, allowing for the free flow of fluid; (6) the topographical organization of these layers in different locations is related to local variations in function (e.g.
View Article and Find Full Text PDFDoctors' knowledge, practices, challenges, and limitations regarding disclosure of bad news: A multicentre study from Pakistan.
J Family Med Prim Care
December 2024
Department of Research Development and Cooperation, Pakistan Medical Research Council, Islamabad, Pakistan.
Background: Breaking bad news is one of the most difficult tasks for practicing doctors, especially for those working in health care specialties where life-threatening diseases are diagnosed and managed routinely. Our aim was to elicit the knowledge and practices of doctors and identify barriers faced by them in disclosure of bad news across the provinces of Pakistan.
Methods: Cross-sectional, multi-centered study supported by an external grant in 15 Government and Private Hospitals across Pakistan.
Using the Behaviour Change Wheel to develop an intervention to improve conversations about recovery on the stroke unit.
PLoS One
January 2025
Academic Unit for Ageing & Stroke Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, United Kingdom.
Background: Understanding recovery is important for patients with stroke and their families, including how much recovery is expected and how long it might take. These conversations can however be uncomfortable for stroke unit staff, particularly when they involve breaking bad news. This study aimed to begin development of a novel complex intervention to improve conversations about recovery on stroke units.
View Article and Find Full Text PDFHow to talk to parents.
Pediatr Radiol
January 2025
Paediatric and prenatal radiology department, Hôpital Timone Enfants, APHM, 264 rue Saint Pierre, Marseille, 13005, France.
Effective communication with the child and his/her parents is of paramount importance in our daily work in paediatric radiology to establish a trusting relationship and enhance satisfaction for both patients and physicians. Although communication skills and empathy can be effectively taught, and efforts have been made in this area in medical schools, there is still much room for improvement, as communication skills tend to decline throughout medical training. Certain methods are valuable for conducting effective consultations with both the child and the parents, not only when breaking bad news.
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