Osteoporosis is the most common systemic skeletal disease characterized by low bone mass, increased bone turnover, and subsequent increased susceptibility to fracture. The aim of this paper was to present a molecular basis of bone remodeling, pathogenesis and different types of osteoporosis. Diagnostic studies, including bone densitometry and laboratory analysis were also reviewed.
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J Clin Endocrinol Metab
April 2020
Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, P.R. China.
Purpose: Genome-wide association studies (GWASs) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with osteoporosis. Most of these SNPs are noncoding variants and could be mapped to enhancers. Transcription factors (TFs) play important roles in gene regulation via enhancers harboring these SNPs; thus, we aimed to identify common regulatory TFs binding to enhancers associated with osteoporosis.
View Article and Find Full Text PDFNat Genet
February 2019
Department of Human Genetics, McGill University, Montréal, Québec, Canada.
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associated with estimated BMD (eBMD), in ~1.
View Article and Find Full Text PDFOsteoporos Int
December 2012
Division of Bone Diseases, Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland.
Postmenopausal osteoporosis is mainly caused by increased bone remodeling resulting from estrogen deficiency. Indications for treatment are based on low areal bone mineral density (aBMD, T-score ≤ -2.5), typical fragility fractures (spine or hip), and more recently, an elevated 10-year fracture probability (by FRAX®).
View Article and Find Full Text PDFPrzegl Lek
October 2011
Katedra i Zakład Chemii Klinicznej i Diagnostyki Laboratoryjnej, Slaski Uniwersytet Medyczny, Sosnowiec.
Osteoporosis is the most common systemic skeletal disease characterized by low bone mass, increased bone turnover, and subsequent increased susceptibility to fracture. The aim of this paper was to present a molecular basis of bone remodeling, pathogenesis and different types of osteoporosis. Diagnostic studies, including bone densitometry and laboratory analysis were also reviewed.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!