AI Article Synopsis
- The human body produces reactive oxygen species (ROS) from immune cells like neutrophils and macrophages, which are important for cellular function but can lead to oxidative stress if levels become too high.
- A study evaluated the levels of myeloperoxidase (MPO) and total antioxidant status (TAS) in the plasma of 28 gastric carcinoma patients at advanced stages before and after surgery.
- Results showed that MPO levels were three times higher and TAS levels were lower in cancer patients compared to a control group, indicating ongoing oxidative stress in these patients that warrants further observation over time.
Article Abstract
The human body is subject to constant effects of reactive oxygen species (ROS). The source of cellular ROS production include activated phagocytes for examples neutrophils and macrophages. ROS at appropriately low level are needed for the proper function of the organism. Uncontrolled increase however is known as oxidative stress and may have serious consequences. The purpose of this investigation was to evaluate in the plasma of gastric carcinoma patients the level of MPO (enzyme of granulocyte) and TAS (total antioxidant status). MPO is a measurement of neutrophils activation and synthesis of ROS. TAS informs about the effect of radicals on neoplastic processes. We tested 28 patients with III and IV stage of gastric carcinoma. Plasma samples were drawn before and 1 and 10 days after surgery operation. The control group consisted of 18 healthy subjects. The plasma level of MPO was measured using a chemiluminescent microparticle immunoassay (CMIA), TAS was measured using colorimetric method. In gastric carcinoma patients before and after operation (1 and 10 day) MPO concentration was 3 times higher in comparison to the control group, but TAS level was decreased. These results suggest the presence of prolonged oxidative stress in malignant disease but it requires long time observation after surgery.
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