AI Article Synopsis
- Researchers investigated the link between specific gene polymorphisms and the risk and severity of rheumatoid arthritis (RA), focusing on various inflammatory response genes.
- They genotyped selected genes in 376 RA patients and 463 healthy controls, finding that the IL8 781 CC genotype was associated with earlier onset of RA.
- The study suggests a potential role for genetic variations in immune response related to RA, but emphasizes the need for more extensive research to clarify these connections.
Article Abstract
Background: Various cytokines and inflammatory mediators are known to be involved in the pathogenesis of rheumatoid arthritis (RA). We hypothesized that polymorphisms in selected inflammatory response and tissue repair genes contribute to the susceptibility to and severity of RA.
Methods: Polymorphisms in TNFA, IL1B, IL4, IL6, IL8, IL10, PAI1, NOS2a, C1INH, PARP, TLR2 and TLR4 were genotyped in 376 Caucasian RA patients and 463 healthy Caucasian controls using single base extension. Genotype distributions in patients were compared with those in controls. In addition, the association of polymorphisms with the need for anti-TNF-α treatment as a marker of RA severity was assessed.
Results: The IL8 781 CC genotype was associated with early onset of disease. The TNFA -238 G/A polymorphism was differentially distributed between RA patients and controls, but only when not corrected for age and gender. None of the polymorphisms was associated with disease severity.
Conclusions: We here report an association between IL8 781 C/T polymorphism and age of onset of RA. Our findings indicate that there might be a role for variations in genes involved in the immune response and in tissue repair in RA pathogenesis. Nevertheless, additional larger genomic and functional studies are required to further define their role in RA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060109 | PMC |
| http://dx.doi.org/10.1186/1471-2350-12-36 | DOI Listing |
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