AI Article Synopsis
- The study used water-suppressed proton nuclear magnetic resonance (NMR) spectroscopy to analyze plasma lipoproteins in guinea pigs injected with either viable or heat-killed tumor cells.
- It was found that as the number of viable tumor cells increased, the NMR resonances became significantly sharper, indicating a specific reaction from the host.
- In contrast, plasma from tumor-free control animals did not show any changes in resonance widths, suggesting a direct link between viable tumor cells and the observed spectral changes.
Article Abstract
Water-suppressed proton nuclear magnetic resonance spectroscopy was used to observe plasma lipoprotein lipid methyl and methylene resonances from guinea pigs which had been injected with viable or heat-killed line 1 or line 10 tumor cells or sterile oil. It was shown that the widths of these resonances became significantly sharper as the number of tumor cells grew. Plasma from tumor-free control animals showed no change in the NMR linewidths. It is concluded that the changes observed reflect a specific host response to viable tumor cells, and in these models there is a reciprocal relationship between the number of viable tumor cells and the linewidths of plasma lipoprotein methyl and methylene resonances.
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| http://dx.doi.org/10.1016/0277-5379(90)90252-o | DOI Listing |
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