AI Article Synopsis
- The tumor was diagnosed as a mixed-type germ cell tumor after a CT-guided biopsy showed necrotizing tissue and immature cartilage-like tissue.
- He underwent 4 cycles of combination chemotherapy, leading to a decrease in tumor size and AFP levels, followed by successful surgical resection with no signs of viable cells or recurrence for over 9 months.
Article Abstract
An 18-year-old man complaining of chest pain was admitted to our hospital. Contrast-enhanced chest computed tomography (CT) showed an anterior mediastinal tumor with patchy enhanced lesions in the peripheral and poorly-enhanced central areas. His serum alpha fetoprotein (AFP) level was high. FDG-PET imaging indicated intense FDG uptake in the mediastinal tumor (SUVmax was 11.2), but no other abnormal FDG uptake, including in his testes, was detected. CT-guided needle biopsy revealed necrotizing tissue, including immature cartilage-like tissue. Based on these clinical features, we diagnosed mixed-type germ cell tumor originating from the mediastinum. Bleomycin, etoposide and cisplatin combination chemotherapy was administered every 3 weeks, for 4 cycles. His serum AFP level declined during the treatment course, and the mediastinal tumor decreased in size. After 4 cycles of chemotherapy, the residual tumor was resected completely and no viable cells were detected in the resected tumor. Tumor recurrence has not been detected for more than 9 months after surgery without adjuvant chemotherapy at the time of writing.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Multilocular thymic cysts- a diagnostic challenge on computed tomography.
World J Clin Cases
January 2025
Department of Diagnostic Radiology, University of Florida College of Medicine, Jacksonville, FL 32209, United States.
A recent case report provided a patient scenario, wherein, a 39-year-old male patient presented with occasional palpitations, headache, and fever. Evaluation of tumor markers did not show any abnormal results. Subsequently, a computed tomography (CT) scan was undertaken, and its findings were affirmative of thymic cancer.
View Article and Find Full Text PDFGiant thymolipoma in a 16-year-old girl with multimodal diagnostic approach and surgical management: a case report.
AME Case Rep
January 2025
Department of Clinical Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Background: Thymolipomas are rare benign mediastinal tumors primarily occurring in young adults, although they can also present in pediatric populations. These tumors are often asymptomatic, but their substantial size can create significant diagnostic and therapeutic challenges, necessitating careful evaluation and management.
Case Description: A teenage girl was diagnosed with a giant thymolipoma, which was discovered incidentally during a routine chest radiograph.
Importance of the multidisciplinary approach in the surgical treatment of giant mediastinal neoplasms: a case series.
AME Case Rep
November 2024
Thoracic Surgery Unit, Campus Bio-Medico University, Rome, Italy.
Background: Many reports described the importance of multidisciplinary meetings in providing oncologic patients with the best treatment strategies. This item improved overall survival, accuracy of staging and adherence to guidelines. For mediastinal neoplasms, collaboration between different surgical skills allows to deal with challenging/impossible surgical procedures.
View Article and Find Full Text PDFEffectiveness of Adjuvant Chemo- and Radiotherapy in Thymic Carcinoma Stage II: A Systematic Review and Meta-Analysis.
Cancer Control
January 2025
Department of Cardiothoracic Surgery, University Clinic of Cologne, Cologne, Germany.
Background: Thymic carcinoma is a rare tumor arising from the epithelial thymic tissue, yet among mediastinal tumors, it is the most common malignant entity. Thymic carcinoma often causes no symptoms and is incidentally discovered. Adjuvant radiotherapy is recommended, particularly in cases of incomplete resection and for stages III and IV, based on current guidelines and existing literature.
View Article and Find Full Text PDFSuccessful Radical Resection Of Masaoka Iii Squamous Cell Thymic Carcinoma Invading Superior Vena Cava And Right Atrium - Case Report.
Port J Card Thorac Vasc Surg
January 2025
Thoracic Surgery Department, Pulido Valente Hospital, CHULN, Lisbon, Portugal.
Introduction: Complete radical resection is crucial for successfully treating thymic carcinomas. However, when the invasion of the great vessels or the heart in Masaoka III and IV stages occurs, the management poses more challenges. The R0 resection often requires neoadjuvant treatment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!