Angioplasty of the proximal portions of major cerebral arteries at the base of the brain has shown promise as a therapy for symptomatic vasospasm after subarachnoid hemorrhage. The blind-ended, single-lumen balloon-dilatation catheter most widely used to date lacks steerability, limiting its application to unbranched stems and single branches at bi- or trifurcation points. To extend the capabilities of cerebral angioplasty, we describe two modifications of the basic technique that have allowed increased selectivity and successful angioplasty of multiple branches, both proximal and distal, involved by vasospasm. Of four patients treated, three showed early improvement in their clinical condition, likely attributable to the angioplasty procedure. Our modifications to the basic angioplasty technique enhanced its success. Further refinement of this technique in the treatment of vasospasm will make it safer in treating this serious and widespread disorder.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334699 | PMC |
Neurosurg Rev
March 2025
Department of Neurosurgery, Iwate Medical University School of Medicine, 2-1-1 Idaidori, Yahaba-cho, Yahaba, Iwate, 028-3694, Japan.
Despite successful management of pulmonary complication with fluid restriction protocol in aneurysmal subarachnoid hemorrhage (aSAH) patients treated with clazosentan, management of symptoms related to mucosal edema, such as diarrhea, stuffy nose, and difficulty in breathing, remains challenging. Hence, we investigated the effect of Goreisan shown to be effective in the treatment of symptoms related with mucosal edema in aSAH patients treated with clazosentan. Patients with aSAH who received clazosentan for vasospasm after aneurysm obliteration were prospectively enrolled in the study.
View Article and Find Full Text PDFAm Heart J
March 2025
Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:
Angina with non-obstructive coronary arteries (ANOCA) is a major cause of chronic coronary syndromes, affecting nearly half of patients with anginal symptoms who undergo invasive coronary angiography. ANOCA may lead to substantial symptom burden, increased risk of adverse cardiac events, increased healthcare utilization due to ongoing symptoms, repeat hospitalizations, and invasive testing. The pathophysiology of ANOCA often involves a variety of coronary disorders, such as coronary microvascular dysfunction, epicardial or microvascular vasospasm and endothelial dysfunction.
View Article and Find Full Text PDFEur Heart J Case Rep
March 2025
Department of Cardiology, Cork University Hospital, Wilton Road, Cork T12 DC4A, Ireland.
Background: Ergometrine is part of the current guideline-directed management of post-partum haemorrhage (PPH). However, it is also a potent vasoconstrictor capable of causing significant coronary artery vasospasm in susceptible individuals.
Case Summary: A 31-year-old primigravida suffered from post-partum haemorrhagic shock and disseminated intravascular coagulation following vaginal delivery.
J Neurointerv Surg
March 2025
Department of Neurosurgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Objective: We hypothesized that stents in stent-assisted coil embolization during endovascular treatment (EVT) may reduce the risk of symptomatic vasospasm following aneurysmal subarachnoid hemorrhage (aSAH) and its treatment. This study aimed to evaluate the impact of stent placement on the occurrence of symptomatic vasospasm, identify the associated risk factors, and analyze symptomatic vasospasm occurrence according to treatment modality and aneurysm location.
Methods: We retrospectively analyzed 546 aSAH patients treated from 2013 to 2022.
Clin Neuropharmacol
March 2025
Division of Neurocritical Care, Department of Neurology, Boston Medical Center and Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
Objectives: Animal studies have suggested that valproic acid (VPA) is neuroprotective in aneurysmal subarachnoid hemorrhage (SAH). However, the effect of VPA on SAH outcomes in humans has not been investigated.
Methods: We conducted a retrospective analysis of 123 patients with nontraumatic SAH.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!