AI Article Synopsis
- miR-483 is found within the IGF2 gene and has previously shown cancer-promoting properties, either by working with IGF2 or by targeting the BBC3/PUMA gene.
- The study indicates that miR-483 expression can be triggered by the oncoprotein β-catenin, which interacts with a specific transcription factor.
- Moreover, miR-483-3p can target β-catenin, creating a feedback loop that is disrupted in cells with mutations in β-catenin, highlighting the intricate regulation involving the IGF2/miR-483 pathway.
Article Abstract
hsa-mir-483 is located within intron 2 of the IGF2 gene. We have previously shown oncogenic features of miR-483-3p through cooperation with IGF2 or by independently targeting the proapoptotic gene BBC3/PUMA. Here we demonstrate that expression of miR-483 can be induced independently of IGF2 by the oncoprotein β-catenin through an interaction with the basic helix-loop-helix protein upstream stimulatory transcription factor 1. We also show that β-catenin itself is a target of miR-483-3p, triggering a negative regulatory loop that becomes ineffective in cells harboring an activating mutation of β-catenin. These results provide insights into the complex regulation of the IGF2/miR-483 locus, revealing players in the β-catenin pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064338 | PMC |
| http://dx.doi.org/10.1073/pnas.1101734108 | DOI Listing |
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