Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, C.P. 14801-970, Araraquara, SP, Brazil.
Published: April 2011
AI Article Synopsis
Article Abstract
Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug doxorubicin.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming 650500, China; Southwest United Graduate School, Kunming 650592, China. Electronic address:
Two new nor-ent-halimane diterpenes and three previously unreported nor-clerodane diterpenes, designated callicaintides A-E (1-5), were isolated from Callicarpa integerrima. Compounds 1 and 2 feature a distinctive 5/6-membered ring system, while compounds 3-5 are characterized by progressively truncated carbon skeletons, containing 18, 17, and 16 carbons, respectively. In addition, four known compounds 6-9 were also identified.
Sw. (Salicaceae) is noted for its morphological and chemical plasticity and pharmacological properties. The present study investigates two of its varieties: var.
School of Pharmacy, Guizhou Medical University, Guiyang 550025, China; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China. Electronic address:
* The structures of these compounds were determined using advanced techniques like spectroscopic analyses and electronic circular dichroism (ECD) calculations.
* Croyunfuranoid D was noted as a rare compound, and some of the new compounds showed significant inhibition of nitric oxide production in specific macrophage cells, particularly compounds 5 and 6.
Natural Product Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
Three butanolides derivatives, grewiifolides A-C, and nine clerodane diterpenes, grewiifolins M-U, as well as a known sterol were isolated from the twigs of Casearia grewiifolia. The chemical structures and configurations of all isolates were established by various spectroscopic means and chemical derivatization. In a cell-based phenotypic assay using the adipogenesis model of human bone marrow mesenchymal stem cells (hBM-MSCs), grewiifolide B significantly promoted adiponectin-secretion with EC value of 24.
Vetriselvan Subramaniyan, Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500, Subang Jaya, Selangor, Malaysia. Electronic address:
3-deoxycaryoptinol (Clerodin), a compound from Clerodendrum infortunatum leaves, shows promising anticancer effects on human monocytic leukemia cells (THP-1).
The research demonstrated clerodin's ability to induce apoptosis via various assays, including Annexin-V/PI for cell death and western blotting for mitochondrial apoptosis markers like caspase-3.
Notably, clerodin specifically targets the G2/M phase of the cell cycle and exhibits minimal toxicity to healthy human blood cells, highlighting its potential as a selective chemotherapeutic agent.
