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Unveiling the Potency of Gardenia Extract Against : Insights from In Vitro and In Vivo Studies.
Biomedicines
January 2025
Center of Excellence in Alternative and Complementary Medicine for Gastrointestinal and Liver Diseases, Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Background And Aim: () could treat various inflammatory diseases. This study aimed to investigate the effects of fruit extract on gastric inflammation and protective mechanisms in ()-induced gastritis. Experimental procedure fruit extract was prepared and analyzed for geniposide content.
View Article and Find Full Text PDFPersistent bilateral sclerouveitis following bimatoprost implantation and removal.
Am J Ophthalmol Case Rep
March 2025
Emory Eye Center, Emory University, Atlanta, GA, USA.
Purpose: To report a case of persistent bilateral sclerouveitis following bilateral bimatoprost implantation (Durysta) that required implant removal and oral steroid course.
Observation: A 75-year-old Caucasian male with no prior ocular inflammation experienced bilateral sclerouveitis post bilateral bimatoprost implantation. Despite implant removal from both eyes, the ocular inflammation persisted, showing cystoid macular edema in both eyes and exudative retinal detachment in the right.
Synthesis, Characterization, and Docking Studies of 1,4-dien as a Potential Impurity in Bimatoprost Drug.
Curr Org Synth
January 2025
Department of Chemistry, GITAM School of Science, GITAM (Deemed to be University), Hyderabad, Telangana, 502329, India.
Introduction: The origin, synthesis, characterization and docking studies of (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,1E,4E)-3-hydroxy-5-phenylpenta-1,4-dien-1-yl)cyclopentyl)-N-ethylhept-5-enamide, an impurity generated in the preparation of an anti-glaucoma agent-Bimatoprost has been described.
Methods: This impurity was controlled by employing 30% Pd/C, and the impurity level was brought to the permissible level, i.e.
Heat-Killed subsp. 557 Extracts Protect Chondrocytes from Osteoarthritis Damage by Reducing Inflammation: An In Vitro Study.
Nutrients
December 2024
Department of Biochemistry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Background: Osteoarthritis (OA) is a chronic condition characterized by joint pain and disability, driven by excessive oxidative stress and inflammatory cytokine production in chondrocytes, resulting in cell death and cartilage matrix breakdown. Our previous study showed that in monosodium iodoacetate (MIA)-induced OA rats, oral administration of heat-killed subsp. 557 (LDL557) could significantly decrease OA progression.
View Article and Find Full Text PDFA case of third trimester uterine prolapse resulting in vaginal delivery by placement of an intravaginal balloon.
J Obstet Gynaecol Res
January 2025
Department of Obstetrics and Gynecology, Kurashiki Central Hospital, Kurashiki, Japan.
Pregnancies complicated by uterine prolapse are rare, occurring in 1 in 10 000 to 15 000 deliveries. We report a case of uterine prolapse at 36 weeks of gestation that resulted in vaginal delivery by placement of a colpeurynter (intravaginal balloon). The patient was a 33-year-old pregnant woman with a history of uterine prolapse during her previous pregnancy.
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