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Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers.
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Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Multiple immune components in the complex and heterogeneous tumor-immune microenvironment (TIME) work cooperatively to promote or impede cancer immunotherapy. Synergistically co-managing multiple immune cells with single agents for advanced antitumor immunity remains desirable but challenging. This In Focus article introduces a triple orthogonal linker (T-Linker)-based multimodal targeting chimera (Multi-TAC) platform, enabling the single-agent-mediated tumor-targeted co-engagement of multiple immune cell types within TIME for potentiated immunotherapy.
View Article and Find Full Text PDFQuantum molecular resonance ameliorates atopic dermatitis through suppression of IL36G and SPRR2B.
BMB Rep
January 2025
Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Department of Medical Sciences, Graduate School, The Catholic University of Korea, Seoul 06591, Korea; Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
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- Atopic dermatitis (AD) is a chronic skin condition that causes itching and inflammation, often treated with corticosteroids like dexamethasone for temporary relief, but not as a cure.
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- Transcriptome analysis identified genes, specifically IL36G and SPRR2B, that's linked to inflammation and skin changes; QMR significantly decreased their expression, suggesting QMR could be a potential new therapy for AD.
Tau reduction impairs nephrocyte function in Drosophila.
BMB Rep
January 2025
Department of Medical Science, Soonchunhyang University, Asan 31538, 2Department of Medical Biotechnology, Soonchunhyang University, Asan 31538, Korea.
Tau, a microtubule-associated protein, is known for its significant involvement in neurodegenerative diseases. While various molecular and immunohistochemical techniques have confirmed the presence of Tau in podocytes, its precise function within these cells remains elusive. In this study, we investigate the role of Tau in kidney podocytes using Drosophila pericardial nephrocytes as a model.
View Article and Find Full Text PDFNeutrophils in MASLD and MASH.
BMB Rep
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Department of Physiology, School of Medicine, Kyungpook National University, Daegu 41944, Korea; Cell & Matrix Research Institute, Kyungpook National University, Daegu 41944, Korea.
Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) and its progressive form, Metabolic Dysfunction Associated Steatohepatitis (MASH), represent significant health concerns associated with the metabolic syndrome. These conditions are characterized by excessive hepatic fat accumulation, inflammation, and potential progression to cirrhosis and hepatocellular carcinoma. Neutrophils are innate immune cells that play a pivotal role in the development of MASLD and MASH.
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