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Diagnosing Epilepsy with Normal Interictal EEG Using Dynamic Network Models.
Ann Neurol
January 2025
Department of Neurology, Comprehensive Epilepsy Center, Johns Hopkins University, Baltimore, MD, USA.
Objective: Whereas a scalp electroencephalogram (EEG) is important for diagnosing epilepsy, a single routine EEG is limited in its diagnostic value. Only a small percentage of routine EEGs show interictal epileptiform discharges (IEDs) and overall misdiagnosis rates of epilepsy are 20% to 30%. We aim to demonstrate how network properties in EEG recordings can be used to improve the speed and accuracy differentiating epilepsy from mimics, such as functional seizures - even in the absence of IEDs.
View Article and Find Full Text PDFEctopic Thyrotropin-Secreting Tumor in the Nasopharynx Causing Central Hyperthyroidism.
JCEM Case Rep
January 2025
Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, London W12 ONN, UK.
We report a 31-year-old man with diarrhea and tachycardia. Diagnostic workup confirmed raised free thyroid hormones with unsuppressed thyroid stimulating hormone (TSH). Laboratory assay and medication interference were excluded.
View Article and Find Full Text PDFParasitemia and antibody response to benznidazole treatment in a cohort of patients with chronic Chagas disease.
Front Parasitol
September 2023
Laboratório de Parasitologia Médica (LIM-46), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.
Background: Evaluating the effectiveness of Chagas disease treatment poses challenges due to the lack of biomarkers for disease progression and therapeutic response. In this study, we aimed to assess the clearance of Trypanosoma cruzi ( parasites in a group of benznidazole (BNZ)-treated chronic Chagas disease patients using high-sensitivity quantitative PCR (qPCR) and track antibody levels through a semiquantitative chemiluminescent assay.
Methods: A total of 102 seropositive patients with previous PCR-positive results were enrolled in the study.
Role of gamma irradiation and disaccharide trehalose to induce immune responses in Syrian hamster model against Iranian SARS-CoV-2 virus isolate.
Vet Res Forum
December 2024
MD Student, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the causative agent of the emerging zoonotic respiratory disease. One of the most important prerequisites for combating emerging diseases is the development of vaccines within a short period of time. In this study, antigen-irradiated, inactivated SARS-CoV-2 viruses and the disaccharide trehalose were used to enhance immune responses in the Syrian hamster.
View Article and Find Full Text PDFThis essay is an attempt to determine what Robert Bernasconi's body of work in Critical Philosophy of Race can teach us about the way in which we, philosophers and professors of philosophy, ought to treat our institutional heritage. What should we make, for instance, of moral claims made by philosophers of the modern era who - tacitly or explicitly - manifested certain levels of endorsement toward the Atlantic Slave Trade? How should we comprehend the conceptual tools that we have inherited from them, knowing that those were formulated alongside justificatory claims for the enslavement of Africans - claims that we now deem undoubtably and universally immoral? I extract from Bernasconi's writings an implicit methodology that can be broken down into three main moves: (1) a historiographical work, akin to Michel Foucault's 'archaeological' method, aimed at uncovering the material conditions that allowed for the emergence of philosophical ideas of the past, (2) a dialectical work aimed at interpreting this collection of historical data through the critical lens of race, and (3) a pedagogical work aimed at transforming the practice of academic philosophy in light of the critique. I conclude that his methodological contribution culminates in an invitation to revisit and transform the past of the institution by treating the history of academic philosophy as philosophically and conceptually relevant rather than merely incidental.
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