This study presents an evaluation of driver performance while text messaging via handheld mobile phones and an in-vehicle texting system. Participants sent and received text messages while driving with an experimenter on a closed-road course, using their personal mobile phones and the vehicle's system. The test vehicle was an instrumented 2010 Mercury Mariner equipped with an OEM in-vehicle system that supports text messaging and voice control of mobile devices via Bluetooth, which was modified to allow text message sending during driving. Twenty participants were tested, 11 younger (19-34) and 9 older (39-51). All participants were regular users of the in-vehicle system, although none had experience with the texting functions. Results indicated that handheld text message sending and receiving resulted in higher mental demand, more frequent and longer glances away from the roadway, and degraded steering measures compared to baseline. Using the in-vehicle system to send messages showed less performance degradation, but still had more task-related interior glance time and higher mental demand than baseline; using the system's text-to-speech functionality for incoming messages showed no differences from baseline. These findings suggest that using handheld phones to send and receive text messages may interfere with drivers' visual and steering behaviors; the in-vehicle system showed improvement, but performance was not at baseline levels during message sending.
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http://dx.doi.org/10.1016/j.aap.2010.11.019 | DOI Listing |
Exp Neurol
January 2025
Department of Neuroscience, The School of Translational Medicine, Monash University, Melbourne, VIC, Australia. Electronic address:
Patients with a traumatic brain injury (TBI) are susceptible to hospital-acquired infections, presenting a significant challenge to an already-compromised immune system. The consequences and mechanisms by which this dual insult worsens outcomes are poorly understood. This study aimed to explore how a systemic immune stimulus (lipopolysaccharide, LPS) influences outcomes following experimental TBI in young adult mice.
View Article and Find Full Text PDFLife Sci
January 2025
Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, China. Electronic address:
Background: Natural glucocorticoids (GCs) have been widely used to treat acute multiple sclerosis (MS) attacks. However, they also cause significant side effects related to immunosuppression. Our previous study found that C16 peptide combined with angiopoietin-1 (Ang-1) inhibited inflammatory cell infiltration and protected blood vessels in animal models of inflammatory neurodegenerative diseases.
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Department of Internal Medicine and Pediatrics, Hepatology Research Unit, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University, Ghent University Hospital, Ghent, Belgium. Electronic address:
Portal hypertension (PH) can cause severe complications in patients with advanced chronic liver disease (aCLD). The pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist lanifibranor reduces portal pressure in preclinical models of aCLD. Since the effect on PH might be secondary to fibrosis improvement, we investigated the effect of lanifibranor on PH, hepatic and splanchnic angiogenesis in mouse models of fibrotic and prehepatic non-fibrotic PH.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Computer Engineering, Brandenburg University of Technology, Cottbus-Senftenberg, 03046 Cottbus, Germany.
Occasionally, four cars arrive at the four legs of an unsignalized intersection at the same time or almost at the same time. If each lane has a stop sign, all four cars are required to stop. In such instances, gestures are used to communicate approval for one vehicle to leave.
View Article and Find Full Text PDFJAMA Netw Open
December 2024
Department of Psychiatry, Washington University in St Louis, St Louis, Missouri.
Importance: Depression and antidepressant use are independently associated with crash risk among older drivers. However, it is unclear what factors impact daily driving that increase safety risk for drivers with depression.
Objective: To examine differences in naturalistic driving behavior and safety between older adults with and without major depressive disorder (MDD).
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