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Increasing dosing intervals for biologics in atopic dermatitis-why, who, when and how?
J Eur Acad Dermatol Venereol
January 2025
Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
Biologics approved and in development for atopic dermatitis offer life-changing clinical efficacy with a relatively banal long-term safety profile requiring no laboratory monitoring. Biologic therapies also have their drawbacks, including high payor cost and the need to be administered as every other week subcutaneous injections. Addressing these concerns, studies of longer dosing intervals have been performed in the formal clinical trial setting and during real-world clinical care.
View Article and Find Full Text PDFNoise-agnostic quantum error mitigation with data augmented neural models.
npj Quantum Inf
January 2025
QICI Quantum Information and Computation Initiative, Department of Computer Science, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Quantum error mitigation, a data processing technique for recovering the statistics of target processes from their noisy version, is a crucial task for near-term quantum technologies. Most existing methods require prior knowledge of the noise model or the noise parameters. Deep neural networks have the potential to lift this requirement, but current models require training data produced by ideal processes in the absence of noise.
View Article and Find Full Text PDFEngineering a Novel NIR RNA-Specific Probe for Tracking Stress Granule Dynamics in Living Cells.
Anal Chem
January 2025
Institute of Physical Science and Information Technology, Information Materials and Intelligent Sensing Laboratory of Anhui Province, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, Anhui 230601, China.
Real-time monitoring of the dynamics of cytosolic RNA-protein condensates, termed stress granules (SGs), is vital for understanding their biological roles in stress response and related disease treatment but is challenging due to the lack of simple and accurate methods. Compared with protein visualization that requires complex transfection procedures, direct RNA labeling offers an ideal alternative for tracking SG dynamics in living cells. Here, we propose a novel molecular design strategy to construct a near-infrared RNA-specific fluorescent probe () for tracking SGs in living cells.
View Article and Find Full Text PDFHighly Porous 3D Ni-MOFs as an Efficient and Enzyme-Mimic Electrochemical Sensing Platform for Glucose in Real Samples of Sweat and Saliva in Biomedical Applications.
ACS Omega
January 2025
Department of Physics, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
Nickel-based metal-organic frameworks, denoted as three-dimensional nickel trimesic acid frameworks (3D Ni-TMAF), are gaining significant attention for their application in nonenzymatic glucose sensing due to their unique properties. Ni-MOFs possess a high surface area, tunable pore structures, and excellent electrochemical activity, which makes them ideal for facilitating electron transfer and enhancing the catalytic oxidation of glucose. This research describes a new electrochemical enzyme-mimic glucose biosensor in biological solutions that utilizes 3D nanospheres Ni-TMAF created layer-by-layer on a highly porous nickel substrate.
View Article and Find Full Text PDFCancer-specific mortality after radical prostatectomy versus radiotherapy in incidental prostate cancer.
Urol Oncol
January 2025
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.
Introduction: To test for cancer specific mortality (CSM) differences after either radical prostatectomy (RP) or radiotherapy (RT) in incidental prostate cancer (IPCa) patients.
Patients And Methods: Within the Surveillance, Epidemiology, and End Results (SEER) database (2004-2015), IPCa patients were identified. Cumulative incidence plots as well as competing risks regression (CRR) models were fitted to address CSM after adjustment for other-cause mortality (OCM).
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