Patients with neurological dysfunction can suffer fevers due to irritation of, or damage to the temperature-regulating center in the brain, or a combination of both. Although hypothermic therapy is a critical treatment nurses often perform, the most effective cooling method has not been studied in the neurological patient. The purpose of this quasi-experimental study was to compare the effectiveness of three methods of fever reduction, and the effect of each on patient shivering. Twenty-one adult febrile neurological patients were randomly placed in one of three temperature reduction groups. One of the temperature reduction protocols was initiated when a subject first became febrile. Rectal temperatures were taken every 15 minutes using an IVAC Temp-Plus thermometer until the subject's temperature returned to 100 degrees F. Subjects were observed for shivering throughout the procedures. The mean time necessary for the subject's temperature to return to 100 degrees F was calculated. A one-way analysis of variance of the time required to reach 100 degrees F was done to determine if a significant difference existed in rate of temperature reduction among the groups. The analysis revealed no statistically significant difference among the three methods, but a chi-square analysis indicated a significant relationship between shivering and the use of a hypothermia blanket.
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http://dx.doi.org/10.1097/01376517-199002000-00006 | DOI Listing |
J Med Chem
January 2025
Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Retrosynthesis is a strategy to analyze the synthetic routes for target molecules in medicinal chemistry. However, traditional retrosynthesis predictions performed by chemists and rule-based expert systems struggle to adapt to the vast chemical space of real-world scenarios. Artificial intelligence (AI) has revolutionized retrosynthesis prediction in recent decades, significantly increasing the accuracy and diversity of predictions for target compounds.
View Article and Find Full Text PDFJ Prim Care Community Health
January 2025
University of Rome Tor Vergata, Roma, Lazio, Italy.
Introduction: Home care workers (HCWs) are paid caregivers who provide support to patients with chronic conditions and functional limitations. Additionally, they provide emotional support to patients and familial support. Although several qualitative studies have been conducted on HCWs, they focused more on studying prevalently the lived experiences about the workplace violence, the end of life, stressor and resilience, during the COVID-19 pandemic or focused more in dementia and heart failure, but not on feelings and working conditions.
View Article and Find Full Text PDFJ Psychosoc Oncol
January 2025
University of Minnesota Medical School, Minneapolis, MN, USA.
Background/purpose: Immunotherapies, such as CAR-T, have revolutionized cancer treatment for some cancers. However, these treatments often require active participation of a family member or friend to act as a caregiver at home for several weeks after infusion. Given the novelty of CAR-T, there is a need to better understand the experience of patients receiving these treatments and their caregivers.
View Article and Find Full Text PDFNurs Res
January 2025
School of Nursing, The University of Texas at Austin.
Background: People with type 2 diabetes mellitus (T2DM) commonly report a higher fatigue intensity than the general population. However, effective fatigue management is lacking because little is known about other fatigue characteristics, including timing, distress, and quality, as well as the potential fatigue subtypes experienced in people with T2DM.
Objective: To describe fatigue intensity, timing, distress, and quality, and identify fatigue subtypes in people with T2DM.
Endocrine
January 2025
Endocrine Unit and Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Purpose: Several studies suggest a linkage between PCOS and autoimmunity with a high frequency of chronic autoimmune thyroiditis (AIT) reported in PCOS patients, however, this subject remains controversial. The aim of this study was to investigate the prevalence of AIT in PCOS women and identify parameters that would serve as independent predictors of AIT.
Methods: Two hundred fifty seven (257) PCOS patients according to the NIH criteria and one hundred forty three (143) controls, women with normal menstrual cycles and without clinical or biochemical hyperandrogenism, were recruited for the study.
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