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Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp. | LitMetric

Leiodermatolide is a structurally unique macrolide, isolated from the deep-water marine sponge ., which exhibits potent antiproliferative activity against a range of human cancer cell lines (IC <10 nM) and dramatic effects on spindle formation in mitotic cells. Its unprecedented polyketide skeleton and stereochemistry were established using a combination of experimental and computational (DP4) NMR methods, and molecular modelling.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875319PMC
http://dx.doi.org/10.1002/anie.201007719DOI Listing

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