Lytic infection by herpes simplex virus (HSV) efficiently inhibits the synthesis of most cellular proteins while a large number of viral proteins is produced, including a host shut off protein (1-3). The inhibitory effect of the protein obviously needs a certain period of time to be fully efficient, but some cellular proteins involved in virus replication still are produced. Examples are those interacting with the regulatory viral proteins V(MW)65 (65K(TIF)) and IE 110 (V(MW) 110, ICPO) (4-8). Certain quiescent cellular genes are activated after infection to express their proteins (9).
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