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17β-Estradiol Abrogates TNF-α-Induced Human Brain Vascular Pericyte Migration by Downregulating miR-638 via ER-β.
Int J Mol Sci
October 2024
Department of Reproductive Endocrinology, University Hospital Zurich, 8952 Schlieren, Switzerland.
Pericytes (PCs) contribute to brain capillary/BBB integrity and PC migration is a hallmark for brain capillary leakage following pro-inflammatory insults. Estradiol promotes endothelial barrier integrity by inhibiting tumor necrosis factor-alpha (TNF-α)-induced PC migration. However, the underlying mechanisms remain unclear.
View Article and Find Full Text PDFGPR30 Agonist G1 Mitigates Sepsis-Induced Cardiac Dysfunction by Inhibiting ACE2/c-FOS-Mediated Necroptosis in Female Mice.
ACS Infect Dis
November 2024
Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Sepsis is a severe inflammatory syndrome with high mortality and morbidity. Sepsis-induced myocardial dysfunction (SIMD) is a common cause of death in sepsis. The female sex is less susceptible to sepsis-related organ dysfunction, although the underlying mechanism of this sex difference remains unclear.
View Article and Find Full Text PDFThe GPR30 Receptor Is Involved in IL-6-Induced Metastatic Properties of MCF-7 Luminal Breast Cancer Cells.
Int J Mol Sci
August 2024
Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Km 9.5 Carretera Morelia-Zinapécuaro, Posta Veterinaria, Morelia 58893, Michoacán, Mexico.
Luminal breast cancer has a high incidence worldwide and poses a severe health threat. Estrogen receptor alpha (ER-α) is activated by 17β-estradiol (E2), and its overexpression promotes cancerous characteristics. Luminal breast cancer is an epithelial type; however, the cytokine IL-6, secreted by cells within the tumor microenvironment, stimulates the epithelial-to-mesenchymal transition (EMT) and promotes metastasis.
View Article and Find Full Text PDFBehavioural changes in young ovariectomized mice via GPR30-dependent serotonergic nervous system.
Eur J Neurosci
October 2024
Department of Functional Brain Activities, United Graduate School of Child Development, Osaka University, Suita, Japan.
Article Synopsis
- Fluctuations in estradiol levels throughout a woman's life, especially during menopause, can impact mental health by affecting the serotonin nervous system, leading to symptoms like depression and anxiety.
- Research using a childhood mouse model showed that ovariectomy (removal of ovaries) at a young age decreased activity levels and altered social preferences.
- The study found that the G protein-coupled receptor 30 plays a significant role in regulating serotonin levels, suggesting it influences behavior changes in response to low estradiol during childhood.
Daidzein's potential in halting neurodegeneration: unveiling mechanistic insights.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India.
Neurological conditions encompassing a wide range of disorders pose significant challenges globally. The complex interactions among signaling pathways and molecular elements play pivotal roles in the initiation and progression of neurodegenerative diseases. Isoflavones have emerged as a promising candidate to fight against neurodegenerative diseases.
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