[Monotherapy with clodronate for tumor-induced hypercalcemia].

Dtsch Med Wochenschr

Medizinische Klinik V, Städtischen Kliniken Darmstadt.

Published: January 1990

AI Article Synopsis

  • A phase II study involved 15 patients (9 women, 6 men; average age 58) undergoing treatment for tumour-induced hypercalcaemia with daily doses of 300 mg clodronate.
  • The participants had various types of cancer, including breast cancer, plasmocytoma, and bronchial carcinoma, and no other calcium-lowering therapies were used.
  • Results showed a significant drop in serum calcium levels within two days, and treatment successfully eliminated hypercalcaemia in 15 out of 16 episodes, suggesting clodronate is an effective standard treatment with minimal side effects.

Article Abstract

In the course of a phase II study 15 patients (nine women and six men; mean age 58 [45-69] years) received 300 mg clodronate daily during a total of 16 episodes of tumour-induced hypercalcaemia. Four women had breast cancer, four patients had plasmocytoma and four had bronchial carcinoma. One woman each had leiomyosarcoma or squamous cell carcinoma of the uterus or pancreatic carcinoma, respectively. No other calcium-lowering treatment, such as forced diuresis, glucocorticoids, calcitonin or mithramycin, was employed. As early as two days after onset of treatment the serum calcium concentration fell significantly from 3.63 +/- 0.42 to 2.80 +/- 0.40 mmol/l. After a mean interval of 4.3 days the hypercalcaemia had been eliminated during 15 of the 16 episodes. The treatment was not adequate in one patient with paraneoplastic hypercalcaemia. The results indicate that this medication is to be recommended as a standard treatment of tumour-induced hypercalcaemia; side effects are minimal.

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Source
http://dx.doi.org/10.1055/s-2008-1064969DOI Listing

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