Splenic infarction is rare in inflammatory diseases of the pancreas, although the spleen and its vessels have an intimate relation with the pancreas. Most reported cases are of focal infarction, and treatment is mostly conservative. The authors report a case of diffuse splenic infarction in a 17-year-old boy with severe acute pancreatitis who presented with massive upper gastrointestinal bleeding and was treated with splenectomy.
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http://dx.doi.org/10.1016/j.amjsurg.2010.03.020 | DOI Listing |
Ann Cardiol Angeiol (Paris)
March 2025
Cardiologie, Centre Hospitalier de Mouscron, Avenue de Fécamp 49, 7700 Mouscron, Belgique.
Left ventricular thrombus (LVT) is a serious complication of both ischemic and non-ischemic cardiomyopathies, with a high risk of morbidity and mortality due to systemic embolism. We present the case of a 73-year-old man with a history of myocardial infarction who subsequently developed an apical thrombus. Seven years after the initial event, this thrombus caused a splenic infarction complicated by an abscessed hematoma.
View Article and Find Full Text PDFEur J Case Rep Intern Med
February 2025
University of Arizona, Tucson, USA.
Unlabelled: This report highlights a rare but significant complication associated with the use of granulocyte-colony stimulating factor (G-CSF) therapy, specifically splenic infarction, in a 67-year-old male with chronic myelomonocytic leukaemia (CMML) undergoing chemotherapy. G-CSFs, such as pegfilgrastim, are frequently used to prevent febrile neutropenia in cancer patients undergoing myelotoxic chemotherapy. While G-CSF is effective in reducing the risk of neutropenia, its administration has been linked to uncommon but severe complications such as splenic infarction and rupture.
View Article and Find Full Text PDFClin Neuroradiol
March 2025
Department of Neuroradiology, School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
Objectives: Throughout the pandemic, it has become evident that COVID-19 should be recognized as a systemic disease that can affect the coagulation system, potentially resulting in arterial thrombotic events (ATE) with partially bulky free-floating clots. This study aimed to investigate the incidence and imaging characteristics of ATE in hospitalized patients with COVID-19 using clinical and imaging data.
Methods: From January 2020 to May 2021, databases of five German tertiary care centers were retrospectively screened for COVID-19 patients with coincidental ATE.
J Dig Dis
March 2025
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
J Neuroinflammation
February 2025
Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA.
Introduction: Elevated circulating IL-6 levels are associated with poorer outcomes after stroke, and increased serum IL-6 levels are linked to a higher risk of stroke. IL-6 binds to soluble IL-6 receptors (sIL-6R) and subsequently to ubiquitously expressed gp130, initiating proinflammatory trans-signaling. This study tested the hypothesis that inhibiting IL-6 trans-signaling by administering soluble (s) gp130 improves long-term functional outcomes in young mice after stroke.
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