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Stoichiometry effect on the structure, coordination and anticancer activity of gold(I/III) bisphosphine complexes.
Dalton Trans
December 2024
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
Rationalizing the impact of oxidation states of Au-based complexes on function require synthetic strategies that allow for conserved molecular formula in Au(I) and their Au(III) counterparts. Oftentimes achieving Au(I) and Au(III) coordination complexes with the same ligand system is challenging due to the reactivity and stability of the starting Au(I) or Au(III) starting materials. Thus, attempts to study the impact of oxidation state on biological function has been elusive.
View Article and Find Full Text PDFEvaluation of Au(III) complexes as Plasmodium falciparum aquaglyceroporin (PfAQP) inhibitors by in silico and in vitro methods.
J Biol Inorg Chem
December 2024
Red Glead Discovery AB, Medicon Village, Scheelevägen 10, 223 63, Lund, Sweden.
The onset of resistance to artemisinin for malaria treatment has stimulated the quest for novel antimalarial drugs. Herein, the gold(III) coordination complexes Aubipy [Au(bipy)Cl] (bipy = 2,2'-bipyridine), Auphen [Au(phen)Cl] (phen = phenanthroline), Auterpy [Au(terpy)Cl] (terpy = 2,2';6',2″-terpyridine), and corresponding hydrolyzed species, have been investigated as inhibitors of the Plasmodium falciparum aquaglyceroporin (PfAQP) protein by computational methods. Through an in-silico approach using an Umbrella Sampling protocol to sample how Aubipy, Auphen, and Auterpy permeate through the PfAQP, their permeability coefficients were estimated using the Inhomogeneous Solubility Diffusion (ISD) model with promising results.
View Article and Find Full Text PDFA simple and highly sensitive colorimetric assay for the visual detection of lead and chromium using ascorbic acid capped gold nanoparticles.
Anal Methods
December 2024
Department of Chemistry, State University of New York, Potsdam, NY 13676, USA.
Lead (Pb) and hexavalent chromium (Cr) are highly toxic pollutants with no safe exposure levels, posing significant health risks globally, especially in developing countries. Current detection methods for these metals are often complex and inaccessible, highlighting the urgent need for innovative approaches. In this study, we present a rapid, cost-effective colorimetric assay utilizing ascorbic acid-capped gold nanoparticles (AuNPs) for the selective detection of Pb and Cr ions at levels recommended by regulatory bodies such as the WHO and EPA.
View Article and Find Full Text PDFEnergy and endoplasmic reticulum stress induction by gold(III) dithiocarbamate and 2-deoxyglucose synergistically trigger cell death in breast cancer.
J Biol Chem
October 2024
Department of Chemistry, University of Kentucky, Lexington, Kentucky, United States; Center for Pharmaceutical Research and Innovation, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA; Center for Bioelectronics and Nanomedicine, University of Kentucky, Lexington, Kentucky, USA. Electronic address:
The elusiveness of triple-negative breast cancer from targeted therapy has redirected focus toward exploiting the metabolic shortcomings of these highly metastatic subtypes of breast cancer. Cueing from the metabolic heterogeneity of TNBC and the exposition of the dual dependence of some TNBCs on OXPHOS and glycolysis for ATP, we herein report the efficacy of cotreatment of TNBCs with an OXPHOS inhibitor, 2a and 2DG, a potent glycolysis inhibitor. 2a-2DG cotreatment inhibited TNBC cell proliferation with IC of ∼5 to 36 times lower than that of 2a alone and over 5000 times lower than IC of 2DG alone.
View Article and Find Full Text PDFMolecular Design and Synthetic Approaches for the Realization of Multichannel Radiative Decay Pathways in Gold(III) Complexes and Their Applications in Organic Light-Emitting Devices.
J Am Chem Soc
November 2024
Institute of Molecular Functional Materials and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Pokfulam 999077, Hong Kong.
A unique class of tridentate diaryltriazine ligand-containing gold(III) complexes with thermally activated delayed fluorescence (TADF) and/or thermally stimulated delayed phosphorescence (TSDP) properties has been designed and synthesized. With a simple structural modification on the coordination of carbazole moiety in the monodentate ligand, a large spectral shift of ∼160 nm (ca. 4900 cm) spanning from sky blue to red emissions has been demonstrated in solid-state thin films.
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