The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O'Shea & Paul, 2010 [4]). To review the putative role of the microenvironment in modulating the commitment of tumor immune surveillance, we use the model of oral premalignant lesions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043348 | PMC |
| http://dx.doi.org/10.6026/97320630005285 | DOI Listing |
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