In this paper the results of concentration of Cu and Ca in pharyngeal tonsils from children exposed and unexposed to tobacco smoke. Concentration of Ca and Cu determination of ICP-AES method with the apparatus Solaar M6 (PJA Solutions). Geometric mean of content of Cu in pharyngeal tonsils girls and boys exposure and unexposure to tobacco smoking was in similar level--2.69-2.99 microg/g. Concentration of Ca in investigated samples was higher in pharyngeal tonsils from children unexposure to tobacco (boys about 200 microg/g, girls about 30 microg/g) in comparison to children exposure to tobacco smoking. In our study was presented cross-correlation analysis between Cu and Ca and other elements and Cluster Analysis.
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Int J Pediatr Otorhinolaryngol
January 2025
Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Ann & Robert H Lurie Children's Hospital of Chicago, Division of Otolaryngology, Chicago, IL, USA.
Background: Cerebral palsy (CP) is the most common neuromuscular disorder in children, and children with CP are at increased risk of respiratory distress potentially requiring tracheostomy placement. Previous studies have characterized indications for tracheostomy in neurologically compromised children, however no studies focus specifically on children with CP. The purpose of this study was to identify the indications for tracheostomy placement, sites of airway obstruction, and rate of decannulation in children with CP.
View Article and Find Full Text PDFJ Virol
January 2025
Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Unlabelled: The tonsils have been identified as a site of replication for Epstein-Barr virus, adenovirus, human papillomavirus, and other respiratory viruses. Human tonsil epithelial cells (HTECs) are a heterogeneous group of actively differentiating cells. Here, we investigated the cellular features and susceptibility of differentiated HTECs to specific influenza viruses, including expression of avian-type and mammalian-type sialic acid (SA) receptors, viral replication dynamics, and the associated cytokine secretion profiles.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Multidisciplinary Institute for Investigation in Pediatric Pathologies (IMIPP), CONICET-GCBA, Pathology Division, Ricardo Gutiérrez Children's Hospital, Buenos Aires C1425EFD, Argentina.
: The Epstein-Barr virus (EBV) infects more than 90 percent of the human population. In pediatric patients, the innate immune response against EBV primary infection plays a key role. Monocytes and macrophages can have distinct functions depending on the microenvironment surrounding them.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Importance: A high infection burden in early childhood is common and a risk factor for later disease development. However, longitudinal birth cohort studies investigating early-life infection burden and later risk of infection and antibiotic episodes are lacking.
Objective: To investigate whether early-life infection burden is associated with a later risk of infection and systemic antibiotic treatment episodes in childhood.
Br J Gen Pract
December 2024
Imperial College London, Department of Primary Care & Public Health, London, United Kingdom.
Background: Little is known about how GP consultation rates for children's respiratory tract infections (RTIs) have changed since the covid-19 pandemic restrictions lifted.
Aim: To describe changes in GP consultation rates for RTIs in children <5 years from 2016-2023.
Design And Setting: Population-based retrospective cohort study using electronic health records.
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