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Background: Extramedullary plasmacytoma (EMP) represents one of the rarer forms of plasma cell malignancies, capable of impacting a variety of tissues and organs throughout the body. The majority of EMP cases are predominantly found in the head and neck region, especially within the laryngopharynx, as well as in the gastrointestinal tract. While there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature, it is important to note that EMP specifically affecting the uvula is exceedingly uncommon.

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Primary solitary extramedullary plasmacytoma is a malignant neoplasm characterized by the monoclonal proliferation of plasma cells outside the bone marrow. The tumor rarely occurs in the sinonasal tract, accounting for about 4% of all non-epithelial sinonasal tumors. Herein, the authors describe a rare case of sinonasal extramedullary plasmacytoma in a 33-year-old man who presented with a 3-month history of progressively increasing nasal mass, causing obstruction.

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Extramedullary plasmacytomas (EMP) are uncommon solitary tumors composed of neoplastic plasma cells occurring outside the bone. These lesions are of clinical significance due to their potential progression to multiple myeloma (MM), a more systemic and serious plasma cell malignancy. Although EMPs primarily arise in the head and neck region, cases involving the oral cavity are particularly rare.

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Introduction And Importance: Solitary extramedullary plasmacytoma (SEP) is a rare plasma cell neoplasm, constituting around 3 % of plasma cell malignancies. SEP typically presents as a single tumor, either in bone or soft tissue, without systemic disease, and is often misdiagnosed due to its nonspecific symptoms. Diagnosis requires biopsy and extensive imaging studies to exclude multiple myeloma and other malignancies.

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Primary pulmonary plasmacytoma: A case report.

Medicine (Baltimore)

December 2024

Department of Respiratory and Critical Care Medicine, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Article Synopsis
  • Extramedullary plasmacytoma is a rare malignant tumor found in tissues outside of bone marrow, with primary pulmonary plasmacytoma (PPP) being particularly uncommon and diagnosed through biopsy.
  • A 65-year-old woman experienced chronic cough and was hospitalized with acute chest pain, where imaging revealed extensive lung inflammation.
  • The diagnosis was confirmed via bronchoscopy, leading to hormone anti-inflammatory treatment; however, the patient was lost to follow-up, emphasizing the need for awareness and biopsy in similar cases to ensure proper diagnosis and management of PPP.
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