AI Article Synopsis

  • The study aimed to investigate the relationship between pregnancy-induced hypertension (PIH) and gestational diabetes mellitus (GDM) with the risk of developing venous thromboembolism (VTE) during pregnancy.
  • A retrospective analysis of over 57,000 pregnancies found that the incidence of VTE was low, with 27 cases detected, and significant risk factors included cesarean sections, multiple pregnancies, PIH, and placenta previa.
  • The findings concluded that while placenta previa and PIH significantly increased the risk of VTE, traditional risk factors like age and GDM were not associated with VTE development.

Article Abstract

Background And Objectives: The aim of this study was to identify the association of pregnancy-induced hypertension (PIH) or gestational diabetes mellitus (GDM) with the development of venous thromboembolism (VTE).

Subjects And Methods: This was a retrospective study of 57,009 pregnancies during 2002-2008 at Cheil General Hospital, Kwandong University. The diagnosis of VTE {deep vein thrombosis or pulmonary embolism (PE)} was based on clot visualization via ultrasound or computed tomography.

Results: In total, 27 cases (PE, 20 cases) were detected. The incidence of VTE was 0.47 per 1,000 pregnancies. To determine risk factors associated with pregnancy-induced VTE, univariate analysis using a chi-square test was performed. Cesarean (C)-section, multiple pregnancy, PIH, placenta previa, and assisted reproduction technique (ART) were statistically significant compared to the controls (all, p=0.000). However, age, premature rupture of membrane, and GDM were not statistically related to VTE. Logistic regression analysis was used to calculate the odds ratios for the risk factors. Placenta previa showed a 12.6-fold higher risk, while PIH had a 9.8-fold higher risk for the occurrence of VTE. C-section and ART procedures increased the risk of VTE by 4.2 times compared to that of the controls.

Conclusion: Placenta previa and PIH were significant risk factors for VTE, whereas the known traditional risk factors of increased age and GDM were not found to be associated with VTE.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040399PMC
http://dx.doi.org/10.4070/kcj.2011.41.1.23DOI Listing

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