J Neuroimmunol
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Published: May 2011
Cholinergic anti-inflammatory pathway (CAP) inhibits unrestrained inflammatory response in a variety of experimental models. Limited research has been done yet to examine the mechanisms of activating CAP on bio-behavioral changes such as heart rate (HR), blood pressure (BP), body temperature (BT), locomotor activity (LA), and autonomic nervous activity (ANA). We observed these parameters using telemetry to clarify pathophysiological mechanisms of CAP. Nicotine significantly attenuated LPS-induced changes in HR, BP, LA, and ANA. These changes were accompanied by significant inhibition of TNF-α and IL-1β syntheses. However the LPS-induced physiological responses persisted much longer than the cytokines production. These results indicate that systemic nicotine treatment inhibits LPS-induced cytokines production and attenuates the associated physiological and behavioral sickness responses.
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http://dx.doi.org/10.1016/j.jneuroim.2011.02.004 | DOI Listing |
Cochrane Database Syst Rev
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Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
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Institute for Mental Health and Policy Research, Centre for Addiction and Mental Health, Toronto, Canada.
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Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jalan Raya Bandung-Sumedang KM 21, Sumedang, 45363, Indonesia.
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