Texaphyrins: tumor localizing redox active expanded porphyrins.

Anticancer Agents Med Chem

Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712-0165, USA.

Published: February 2011

Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimental use in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224805PMC
http://dx.doi.org/10.2174/187152011795255894DOI Listing

Publication Analysis

Top Keywords

expanded porphyrins
8
texaphyrins tumor
4
tumor localizing
4
localizing redox
4
redox active
4
active expanded
4
porphyrins texaphyrins
4
texaphyrins class
4
class tumor
4
tumor selective
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!